Signal processing and generation of bioactive nitric oxide in a model prototissue

Songyang Liu; Yanwen Zhang; Xiaoxiao He; Mei Li; Jin Huang; Xiaohai Yang; Kemin Wang; Stephen Mann; Jianbo Liu

doi:10.1038/s41467-022-32941-6

Nature Communications (Sep 2022)

Signal processing and generation of bioactive nitric oxide in a model prototissue

Songyang Liu,
Yanwen Zhang,
Xiaoxiao He,
Mei Li,
Jin Huang,
Xiaohai Yang,
Kemin Wang,
Stephen Mann,
Jianbo Liu

Affiliations

Songyang Liu: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University
Yanwen Zhang: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University
Xiaoxiao He: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University
Mei Li: Centre for Protolife Research, School of Chemistry and Max Planck-Bristol Centre for Minimal Biology, University of Bristol
Jin Huang: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University
Xiaohai Yang: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University
Kemin Wang: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University
Stephen Mann: Centre for Protolife Research, School of Chemistry and Max Planck-Bristol Centre for Minimal Biology, University of Bristol
Jianbo Liu: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University

DOI: https://doi.org/10.1038/s41467-022-32941-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

A challenge for synthetic biology is the design and construction of prototissue. Here, the authors spatially segregate layers of enzyme-decorated coacervate protocells as a model prototissue capable of chemical signal processing and modulating outputs of nitric oxide to inhibit blood clot formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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