Anthocyanins Formulated with Carboxymethyl Starch for Gastric and Intestinal Delivery

Luiz Bruno De Sousa Sabino; Francesco Copes; Solène Saulais; Edy Sousa De Brito; Ivanildo José Da Silva Júnior; Tien Canh Le; Mircea Alexandru Mateescu; Diego Mantovani

doi:10.3390/molecules27217271

Molecules (Oct 2022)

Anthocyanins Formulated with Carboxymethyl Starch for Gastric and Intestinal Delivery

Luiz Bruno De Sousa Sabino,
Francesco Copes,
Solène Saulais,
Edy Sousa De Brito,
Ivanildo José Da Silva Júnior,
Tien Canh Le,
Mircea Alexandru Mateescu,
Diego Mantovani

Affiliations

Luiz Bruno De Sousa Sabino: Department of Chemical Engineering, Federal University of Ceará, Av. Mister Hull, 2977, Campus Universitário do Pici, Fortaleza 60356-000, Ceará, Brazil
Francesco Copes: Laboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgy and Materials Engineering & CHU de Québec, Regenerative Medicine Division, Laval University, Quebec City, QC G1V 0A6, Canada
Solène Saulais: Department of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada
Edy Sousa De Brito: Embrapa Agroindústria Tropical, R. Dra Sara Mesquita, 2270, Fortaleza 60511-110, Ceará, Brazil
Ivanildo José Da Silva Júnior: Department of Chemical Engineering, Federal University of Ceará, Av. Mister Hull, 2977, Campus Universitário do Pici, Fortaleza 60356-000, Ceará, Brazil
Tien Canh Le: Department of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada
Mircea Alexandru Mateescu: Department of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada
Diego Mantovani: Laboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgy and Materials Engineering & CHU de Québec, Regenerative Medicine Division, Laval University, Quebec City, QC G1V 0A6, Canada

DOI: https://doi.org/10.3390/molecules27217271
Journal volume & issue: Vol. 27, no. 21
p. 7271

Abstract

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Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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