Modulation of Voltage-Gated Calcium Influx by Electromagnetic Irradiation With Terahertz Gaussian Pulse

Wenfei Bo; Lianghao Guo; Kaicheng Wang; Jialu Ma; Jingchao Tang; Zhe Wu; Baoqing Zeng; Yubin Gong

doi:10.1109/ACCESS.2020.3010870

IEEE Access (Jan 2020)

Modulation of Voltage-Gated Calcium Influx by Electromagnetic Irradiation With Terahertz Gaussian Pulse

Wenfei Bo,
Lianghao Guo,
Kaicheng Wang,
Jialu Ma,
Jingchao Tang,
Zhe Wu,
Baoqing Zeng,
Yubin Gong

Affiliations

Wenfei Bo: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Lianghao Guo: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Kaicheng Wang: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Jialu Ma: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Jingchao Tang: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Zhe Wu: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Baoqing Zeng: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China
Yubin Gong: ORCiD; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China

DOI: https://doi.org/10.1109/ACCESS.2020.3010870
Journal volume & issue: Vol. 8
pp. 133673 – 133680

Abstract

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The voltage-gated calcium influxes modulated with terahertz Gaussian pulse is presented in this paper, and temperature rise is evaluated to monitor the terahertz thermal effects involved in the modulation. From the numerical results, inhibition effect on voltage-gated calcium influx because of the loss of the influx from electric drift is transparently revealed in the modulation with terahertz Gaussian pulse. And the inhibition effect becomes significant reflected by considerable reduction in voltage-gated calcium influx as the irradiated amplitude is raised intense enough. Compared to the terahertz sinusoidal wave, Gaussian pulse reduces the inhibition effect dramatically. The decrease in the increment of intracellular calcium concentration with the irradiated amplitude due to the inhibition effect is substantially relieved by the modulation of the calcium influx with terahertz Gaussian pulse. The thermal analyses reveal that the modulation is non-thermal effect. Meanwhile, to raise the intracellular calcium concentration to a same amount by means of the voltage-gated calcium influx, application of terahertz Gaussian pulse induces much less concurrent temperature rise than application of terahertz sinusoidal wave of the same amplitude that is intense enough to cause the inhibition effect. Additionally, terahertz Gaussian pulse irradiation remains the dependence of the increment of the calcium concentration on the irradiated time duration and frequency in terahertz sinusoidal wave irradiation. These numerical results lay the theoretical basis for the modulation of voltage-gated calcium fluxes with terahertz Gaussian pulse and for further potential clinical applications of terahertz Gaussian pulse.

Published in IEEE Access

ISSN: 2169-3536 (Online)
Publisher: IEEE
Country of publisher: United States
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering
Website: https://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=6287639

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