Nature Communications (Jul 2022)
Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma
- Yoshiaki Yasumizu,
- Naganari Ohkura,
- Hisashi Murata,
- Makoto Kinoshita,
- Soichiro Funaki,
- Satoshi Nojima,
- Kansuke Kido,
- Masaharu Kohara,
- Daisuke Motooka,
- Daisuke Okuzaki,
- Shuji Suganami,
- Eriko Takeuchi,
- Yamami Nakamura,
- Yusuke Takeshima,
- Masaya Arai,
- Satoru Tada,
- Meinoshin Okumura,
- Eiichi Morii,
- Yasushi Shintani,
- Shimon Sakaguchi,
- Tatsusada Okuno,
- Hideki Mochizuki
Affiliations
- Yoshiaki Yasumizu
- Department of Neurology, Graduate School of Medicine, Osaka University
- Naganari Ohkura
- Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University
- Hisashi Murata
- Department of Neurology, Graduate School of Medicine, Osaka University
- Makoto Kinoshita
- Department of Neurology, Graduate School of Medicine, Osaka University
- Soichiro Funaki
- Department of General Thoracic Surgery, Graduate School of Medicine, Osaka University
- Satoshi Nojima
- Department of Pathology, Graduate School of Medicine, Osaka University
- Kansuke Kido
- Department of Pathology, Graduate School of Medicine, Osaka University
- Masaharu Kohara
- Department of Pathology, Graduate School of Medicine, Osaka University
- Daisuke Motooka
- Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University
- Daisuke Okuzaki
- Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University
- Shuji Suganami
- Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
- Eriko Takeuchi
- Department of Neurology, Graduate School of Medicine, Osaka University
- Yamami Nakamura
- Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University
- Yusuke Takeshima
- Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University
- Masaya Arai
- Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University
- Satoru Tada
- Department of Neurology, Graduate School of Medicine, Osaka University
- Meinoshin Okumura
- Department of General Thoracic Surgery, National Hospital Organization Osaka Toneyama Medical Center
- Eiichi Morii
- Department of Pathology, Graduate School of Medicine, Osaka University
- Yasushi Shintani
- Department of General Thoracic Surgery, Graduate School of Medicine, Osaka University
- Shimon Sakaguchi
- Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University
- Tatsusada Okuno
- Department of Neurology, Graduate School of Medicine, Osaka University
- Hideki Mochizuki
- Department of Neurology, Graduate School of Medicine, Osaka University
- DOI
- https://doi.org/10.1038/s41467-022-31951-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Myasthenia Gravis and thymoma are frequently associated with patients suffering from both diseases. Here the authors perform single cell sequencing of thymoma and find that there are autoimmune antigens such as neuromuscular proteins expressed aberrantly in neuromuscular mTECs in patients with both diseases.
