Egyptian Rheumatology and Rehabilitation (Apr 2023)

Egyptian recommendations for the management of systemic lupus erythematosus: a consensus, evidence-based, clinical practice guidelines for treat-to-target management

  • Yasser El Miedany,
  • Khaled Elhadidi,
  • Geilan Abdelmoneim Mahmoud,
  • Mohammed Hassan Abu-Zaid,
  • Atef Abdelazim Mahmoud,
  • Maha El Gaafary,
  • Nadia Kamel,
  • Nihal Ahmed Fathi,
  • Ahmed Abdel Nasser,
  • Waleed Hassan,
  • Mervat Eissa,
  • Eman Sarhan,
  • Essam Aboalfadl,
  • Ahmed Ezzat Mansour,
  • Mohamed Mortada,
  • Nermeen Ahmed Fouad,
  • Ismail Elaraby,
  • Rehab Elnemr,
  • Basma M. Medhat,
  • Sally S. Mohamed,
  • Rehab Ali Ibrahim,
  • Samar abd Alhamed Tabra,
  • Sally Saber,
  • Genny Franklin,
  • Abir Mokbel

DOI
https://doi.org/10.1186/s43166-023-00187-9
Journal volume & issue
Vol. 50, no. 1
pp. 1 – 19

Abstract

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Abstract Background Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by having varying clinical presentation, severity, unpredictable course as well as outcomes. Recent disease-modifying conventional and biologic agents have enhanced rates of attaining both short- and long-term management goals, including minimization of glucocorticoid dose and use. This study was carried out to develop an up-to-date evidence-based, consensus on clinical practice guidelines for treat-to-target management of systemic lupus erythematosus in adults. Results The response rate to the online questionnaires, sent to the expert panel who participated in the three rounds, was 95.5%. At the end of round 3, a total of 14 recommendation sections were proposed for the T2T management of patients with SLE. Agreement with the recommendations (rank 7–9) ranged from 90.9–100%. Consensus was reached (i.e., ≥ 80% of respondents strongly agreed or agreed) on the proposed statements. Conclusion These recommendations provide a consensus on the treat-to-target management of patients with SLE. They provide strategies to reach optimal outcomes in common clinical scenarios, based on a combination of evidence and expert opinion.

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