Materials Today Bio (Dec 2024)
Three-dimensional gas-foamed scaffolds decorated with metal phenolic networks for cartilage regeneration
- Yujie Chen,
- Wei Xu,
- Zhen Pan,
- Bohui Li,
- Xiumei Mo,
- Yucai Li,
- Jielin Wang,
- Yuan Wang,
- Zhenyuan Wei,
- Yicheng Chen,
- Zhaopu Han,
- Chen Lin,
- Yu Liu,
- Xiaojian Ye,
- Jiangming Yu
Affiliations
- Yujie Chen
- Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai, 200336, China; Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
- Wei Xu
- Department of Plastic Surgery, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, China
- Zhen Pan
- Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai, 200336, China; Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
- Bohui Li
- Plastic Surgery Institute, Shandong Second Medical University, Weifang, Shandong, 261053, China; Shanghai Key Laboratory of Tissue Engineering, Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Stem Cell Institute, Shanghai Jiao Tong University School of Medicine, Huangpu, Shanghai, 200001, China
- Xiumei Mo
- Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Biological Science and Medical Engineering, Donghua University, Songjiang, Shanghai, 201600, China
- Yucai Li
- Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai, 200336, China; Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
- Jielin Wang
- Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai, 200336, China; Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
- Yuan Wang
- Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
- Zhenyuan Wei
- Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai, 200336, China; Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
- Yicheng Chen
- Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai, 200336, China; Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
- Zhaopu Han
- Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai, 200336, China; Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China
- Chen Lin
- Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, Pudong New Area, Shanghai, 200120, China
- Yu Liu
- Plastic Surgery Institute, Shandong Second Medical University, Weifang, Shandong, 261053, China; Shanghai Key Laboratory of Tissue Engineering, Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Stem Cell Institute, Shanghai Jiao Tong University School of Medicine, Huangpu, Shanghai, 200001, China; Corresponding author. Plastic Surgery Institute, Shandong Second Medical University, Weifang, Shandong, 261053, China.
- Xiaojian Ye
- Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai, 200336, China; Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Corresponding author. Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
- Jiangming Yu
- Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai, 200336, China; Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; Corresponding author. Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai, 200336, China.
- Journal volume & issue
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Vol. 29
p. 101249
Abstract
Inflammation is a major impediment to the healing of cartilage injuries, yet bioactive scaffolds suitable for cartilage repair in inflammatory environments are extremely rare. Herein, we utilized electrospinning to fabricate a two-dimensional nanofiber scaffold (2DS), which was then subjected to gas foaming to obtain a three-dimensional scaffold (3DS). 3DS was modified with metal phenolic networks (MPNs) composed of epigallocatechin gallate (EGCG) and strontium ions (Sr2+) to afford a MPNs-modified 3D scaffold (3DS-E). Gas-foamed scaffold exhibited multilayered structure conducive to cellular infiltration and proliferation. Compared to other groups, 3DS-E better preserved chondrocytes under interleukin (IL)-1β induced inflammatory environment, showing less apoptosis of chondrocytes and higher expression of cartilage matrix. Additionally, 3DS-E facilitated the regeneration of more mature cartilage in vivo, reduced cell apoptosis, and decreased the expression of pro-inflammatory cytokines.Taken together, 3DS-E may offer an ideal candidate for cartilage regeneration.
