Biocatalytic routes to stereo-divergent iridoids

Néstor J. Hernández Lozada; Benke Hong; Joshua C. Wood; Lorenzo Caputi; Jérôme Basquin; Ling Chuang; Maritta Kunert; Carlos E. Rodríguez López; Chloe Langley; Dongyan Zhao; C. Robin Buell; Benjamin R. Lichman; Sarah E. O’Connor

doi:10.1038/s41467-022-32414-w

Nature Communications (Aug 2022)

Biocatalytic routes to stereo-divergent iridoids

Néstor J. Hernández Lozada,
Benke Hong,
Joshua C. Wood,
Lorenzo Caputi,
Jérôme Basquin,
Ling Chuang,
Maritta Kunert,
Carlos E. Rodríguez López,
Chloe Langley,
Dongyan Zhao,
C. Robin Buell,
Benjamin R. Lichman,
Sarah E. O’Connor

Affiliations

Néstor J. Hernández Lozada: Max-Planck Institute for Chemical Ecology, Department of Natural Product Biosynthesis
Benke Hong: Max-Planck Institute for Chemical Ecology, Department of Natural Product Biosynthesis
Joshua C. Wood: Center for Applied Genetic Technologies, University of Georgia
Lorenzo Caputi: Max-Planck Institute for Chemical Ecology, Department of Natural Product Biosynthesis
Jérôme Basquin: Max-Planck Institute for Biochemistry, Department of Structural Cell Biology
Ling Chuang: Max-Planck Institute for Chemical Ecology, Department of Natural Product Biosynthesis
Maritta Kunert: Max-Planck Institute for Chemical Ecology, Department of Natural Product Biosynthesis
Carlos E. Rodríguez López: Max-Planck Institute for Chemical Ecology, Department of Natural Product Biosynthesis
Chloe Langley: Max-Planck Institute for Chemical Ecology, Department of Natural Product Biosynthesis
Dongyan Zhao: Center for Applied Genetic Technologies, University of Georgia
C. Robin Buell: Center for Applied Genetic Technologies, University of Georgia
Benjamin R. Lichman: University of York, Department of Biology, Centre for Agricultural Products
Sarah E. O’Connor: Max-Planck Institute for Chemical Ecology, Department of Natural Product Biosynthesis

DOI: https://doi.org/10.1038/s41467-022-32414-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Iridoid compounds are an important class of natural products. Here, the authors report on the discovery and engineering of nepetalactol-related short chain reductases and their application for the biosynthesis of nepetalactol or nepetalactone stereoisomers, as a versatile system for the production of the iridoid natural product scaffold.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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