Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols

Zhaofei Zhang; Chuntian Qiu; Yangsen Xu; Qing Han; Junwang Tang; Kian Ping Loh; Chenliang Su

doi:10.1038/s41467-020-18458-w

Nature Communications (Sep 2020)

Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols

Zhaofei Zhang,
Chuntian Qiu,
Yangsen Xu,
Qing Han,
Junwang Tang,
Kian Ping Loh,
Chenliang Su

Affiliations

Zhaofei Zhang: International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology of Ministry of Education, Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong Province, Institute of Microscale Optoeletronics, Shenzhen University
Chuntian Qiu: International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology of Ministry of Education, Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong Province, Institute of Microscale Optoeletronics, Shenzhen University
Yangsen Xu: International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology of Ministry of Education, Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong Province, Institute of Microscale Optoeletronics, Shenzhen University
Qing Han: Department of Chemical Engineering, University College London
Junwang Tang: Department of Chemical Engineering, University College London
Kian Ping Loh: Department of Chemistry and Centre for Advanced 2D Materials (CA2DM), National University of Singapore
Chenliang Su: International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology of Ministry of Education, Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong Province, Institute of Microscale Optoeletronics, Shenzhen University

DOI: https://doi.org/10.1038/s41467-020-18458-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 8

Abstract

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Controllable deuteration of N-alkyl amines is crucial in drug-development as they constitute over 50% of the top-selling drugs. Here, the authors report a polymeric semiconductor acting as photocatalyst in water-splitting and in isotope alkanol-oxidation by photoexcited electron-hole pairs, and furnishing deuterated amines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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