Self-healing polyurethane-elastomer with mechanical tunability for multiple biomedical applications in vivo

Chenyu Jiang; Luzhi Zhang; Qi Yang; Shixing Huang; Hongpeng Shi; Qiang Long; Bei Qian; Zenghe Liu; Qingbao Guan; Mingjian Liu; Renhao Yang; Qiang Zhao; Zhengwei You; Xiaofeng Ye

doi:10.1038/s41467-021-24680-x

Nature Communications (Jul 2021)

Self-healing polyurethane-elastomer with mechanical tunability for multiple biomedical applications in vivo

Chenyu Jiang,
Luzhi Zhang,
Qi Yang,
Shixing Huang,
Hongpeng Shi,
Qiang Long,
Bei Qian,
Zenghe Liu,
Qingbao Guan,
Mingjian Liu,
Renhao Yang,
Qiang Zhao,
Zhengwei You,
Xiaofeng Ye

Affiliations

Chenyu Jiang: Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Luzhi Zhang: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-dimension Materials (Donghua University), College of Materials Science and Engineering, Donghua University
Qi Yang: Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Shixing Huang: Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Hongpeng Shi: Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Qiang Long: Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Bei Qian: Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Zenghe Liu: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-dimension Materials (Donghua University), College of Materials Science and Engineering, Donghua University
Qingbao Guan: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-dimension Materials (Donghua University), College of Materials Science and Engineering, Donghua University
Mingjian Liu: Department Neuro Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Renhao Yang: Department Orthopedics Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Qiang Zhao: Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Zhengwei You: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-dimension Materials (Donghua University), College of Materials Science and Engineering, Donghua University
Xiaofeng Ye: Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine

DOI: https://doi.org/10.1038/s41467-021-24680-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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The unique properties of self-healing materials hold great potential in the field of biomedical engineering. Here, the authors designed a series of biodegradable and biocompatible self-healing elastomers with tunable mechanical properties, and apply them to various disease models in vivo, including aortic aneurism, bone fracture and nerve amputation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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