Heritable DNA methylation marks associated with susceptibility to breast cancer

Jihoon E. Joo; James G. Dowty; Roger L. Milne; Ee Ming Wong; Pierre-Antoine Dugué; Dallas English; John L. Hopper; David E. Goldgar; Graham G. Giles; Melissa C. Southey; kConFab

doi:10.1038/s41467-018-03058-6

Nature Communications (Feb 2018)

Heritable DNA methylation marks associated with susceptibility to breast cancer

Jihoon E. Joo,
James G. Dowty,
Roger L. Milne,
Ee Ming Wong,
Pierre-Antoine Dugué,
Dallas English,
John L. Hopper,
David E. Goldgar,
Graham G. Giles,
Melissa C. Southey,
kConFab

Affiliations

Jihoon E. Joo: Department of Pathology, The University of Melbourne
James G. Dowty: Centre for Epidemiology and Biostatistics, The University of Melbourne
Roger L. Milne: Centre for Epidemiology and Biostatistics, The University of Melbourne
Ee Ming Wong: Department of Pathology, The University of Melbourne
Pierre-Antoine Dugué: Centre for Epidemiology and Biostatistics, The University of Melbourne
Dallas English: Centre for Epidemiology and Biostatistics, The University of Melbourne
John L. Hopper: Centre for Epidemiology and Biostatistics, The University of Melbourne
David E. Goldgar: Department of Pathology, The University of Melbourne
Graham G. Giles: Centre for Epidemiology and Biostatistics, The University of Melbourne
Melissa C. Southey: Department of Pathology, The University of Melbourne
kConFab

DOI: https://doi.org/10.1038/s41467-018-03058-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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DNA methylation is associated with breast cancer risk. Here the authors measure DNA methylation in the blood of individuals from 25 Australian families with multiple cases of breast cancer but not known mutations associated with breast cancer risk to identify possible heritable methylation markers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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