Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment

Abstract

Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early state of AD. This review article outlines oxidative stress in MCI and how this can account for neuronal loss and potential therapeutic strategies to slow progression to AD.

Keywords

• lipid peroxidation
• Abeta and oxidative stress
• neuronal loss
• key metabolic pathways involved in MCI
• potential therapeutic strategies for MCI