Influence of Platelet Aggregation Modulators on Cyclic AMP Production in Human Thrombocytes

Abstract

Background: Cyclic AMP is a powerful inhibitor of platelet aggregation. In the present study we examined the effect of platelet aggregation modulators on cyclic AMP content in human thrombocytes. Of the agents we tested, lactoferrin, wortmannin, quercetin and amiloride are platelet aggregation inhibitors, whereas ouabain is a platelet activator.

Keywords

• cyclic AMP
• human platelets
• lactoferrin