β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis

Silvia Giannini; Melissa M. Lee-Sundlov; Leonardo Rivadeneyra; Christian A. Di Buduo; Robert Burns; Joseph T. Lau; Hervé Falet; Alessandra Balduini; Karin M. Hoffmeister

doi:10.1038/s41467-019-14178-y

Nature Communications (Jan 2020)

β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis

Silvia Giannini,
Melissa M. Lee-Sundlov,
Leonardo Rivadeneyra,
Christian A. Di Buduo,
Robert Burns,
Joseph T. Lau,
Hervé Falet,
Alessandra Balduini,
Karin M. Hoffmeister

Affiliations

Silvia Giannini: Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Melissa M. Lee-Sundlov: Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Leonardo Rivadeneyra: Translational Glycomics Center, Blood Research Institute, Versiti
Christian A. Di Buduo: Laboratory of Biochemistry, Biotechnology, and Advanced Diagnosis, Department of Molecular Medicine, University of Pavia
Robert Burns: Translational Glycomics Center, Blood Research Institute, Versiti
Joseph T. Lau: Department of Molecular and Cellular Biology, Roswell Park Cancer Institute
Hervé Falet: Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Alessandra Balduini: Laboratory of Biochemistry, Biotechnology, and Advanced Diagnosis, Department of Molecular Medicine, University of Pavia
Karin M. Hoffmeister: Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-019-14178-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

Read online

Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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