Journal of Clinical Medicine (Jan 2022)
Anticoagulation Prior to COVID-19 Infection Has No Impact on 6 Months Mortality: A Propensity Score–Matched Cohort Study
- Marcin Protasiewicz,
- Konrad Reszka,
- Wojciech Kosowski,
- Barbara Adamik,
- Wojciech Bombala,
- Adrian Doroszko,
- Damian Gajecki,
- Jakub Gawryś,
- Maciej Guziński,
- Maria Jedrzejczyk,
- Krzysztof Kaliszewski,
- Katarzyna Kilis-Pstrusinska,
- Bogusława Konopska,
- Agnieszka Kopec,
- Krzysztof Kujawa,
- Anna Langner,
- Anna Larysz,
- Weronika Lis,
- Lilla Pawlik-Sobecka,
- Joanna Gorka-Dynysiewicz,
- Marta Rosiek-Biegus,
- Agnieszka Matera-Witkiewicz,
- Tomasz Matys,
- Michał Pomorski,
- Mateusz Sokolski,
- Janusz Sokołowski,
- Anna Tomasiewicz-Zapolska,
- Katarzyna Madziarska,
- Ewa A Jankowska
Affiliations
- Marcin Protasiewicz
- Institute of Heart Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
- Konrad Reszka
- Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland
- Wojciech Kosowski
- Institute of Heart Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
- Barbara Adamik
- Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Wojciech Bombala
- Statistical Analysis Centre, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Adrian Doroszko
- Clinical Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Damian Gajecki
- Clinical Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Jakub Gawryś
- Clinical Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Maciej Guziński
- Department of Radiology, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Maria Jedrzejczyk
- Department of Nursing and Obstetrics, Division of Internal Medicine Nursing, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Krzysztof Kaliszewski
- Clinical Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Katarzyna Kilis-Pstrusinska
- Clinical Department of Paediatric Nephrology, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Bogusława Konopska
- Department of Pharmaceutical Biochemistry, Division of Pharmaceutical Biochemistry, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Agnieszka Kopec
- Clinical Department of Internal Medicine, Pneumology and Allergology, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Krzysztof Kujawa
- Statistical Analysis Centre, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Anna Langner
- Institute of Heart Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
- Anna Larysz
- Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland
- Weronika Lis
- Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland
- Lilla Pawlik-Sobecka
- Division of Basic Sciences, Faculty of Health Sciences, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Joanna Gorka-Dynysiewicz
- Department of Pharmaceutical Biochemistry, Division of Pharmaceutical Biochemistry, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Marta Rosiek-Biegus
- Clinical Department of Internal Medicine, Pneumology and Allergology, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Agnieszka Matera-Witkiewicz
- Screening of Biological Activity Assays and Collection of Biological Material Lab., Wroclaw Medical University Biobank, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Tomasz Matys
- Clinical Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Michał Pomorski
- 2nd Department of Gynaecology and Obstetrics, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Mateusz Sokolski
- Institute of Heart Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
- Janusz Sokołowski
- Clinical Department of Emergency Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Anna Tomasiewicz-Zapolska
- Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland
- Katarzyna Madziarska
- Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland
- Ewa A Jankowska
- Institute of Heart Diseases, University Hospital, 50-367 Wroclaw, Poland
- DOI
- https://doi.org/10.3390/jcm11020352
- Journal volume & issue
-
Vol. 11,
no. 2
p. 352
Abstract
The coronavirus disease 2019 (COVID-19) shows high incidence of thromboembolic events in humans. In the present study, we aimed to evaluate if anticoagulation prior to COVID-19 infection may impact clinical profile, as well as mortality rate among patients hospitalized with COVID-19. The study was based on retrospective analysis of medical records of patients with laboratory confirmed SARS-CoV-2 infection. After propensity score matching (PSM), a group of 236 patients receiving any anticoagulant treatment prior to COVID-19 infection (AT group) was compared to 236 patients without previous anticoagulation (no AT group). In 180 days, the observation we noted comparable mortality rate in AT and no AT groups (38.5% vs. 41.1%, p = 0.51). Similarly, we did not observe any statistically significant differences in admission in the intensive care unit (14.1% vs. 9.6%, p = 0.20), intubation and mechanical ventilation (15.0% vs. 11.6%, p = 0.38), catecholamines usage (14.3% vs. 13.8%, p = 0.86), and bleeding rate (6.3% vs. 8.9%, p = 0.37) in both groups. Our results suggest that antithrombotic treatment prior to COVID-19 infection is unlikely to be protective for morbidity and mortality in patients hospitalized with COVID-19.
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