Nature Communications (Oct 2021)

Efficient generative modeling of protein sequences using simple autoregressive models

  • Jeanne Trinquier,
  • Guido Uguzzoni,
  • Andrea Pagnani,
  • Francesco Zamponi,
  • Martin Weigt

DOI
https://doi.org/10.1038/s41467-021-25756-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Deep learning is a powerful tool for the design of novel protein sequences, yet can be computationally very inefficient. Here the authors propose using simple forecasting models to efficiently generate a large number of novel protein structures.