Nature Communications (Dec 2018)
aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability
- Meghan Riddell,
- Akiko Nakayama,
- Takao Hikita,
- Fatemeh Mirzapourshafiyi,
- Takuji Kawamura,
- Ayesha Pasha,
- Mengnan Li,
- Mikio Masuzawa,
- Mario Looso,
- Tim Steinbacher,
- Klaus Ebnet,
- Michael Potente,
- Tomonori Hirose,
- Shigeo Ohno,
- Ingrid Fleming,
- Stefan Gattenlöhner,
- Phyu P. Aung,
- Thuy Phung,
- Osamu Yamasaki,
- Teruki Yanagi,
- Hiroshi Umemura,
- Masanori Nakayama
Affiliations
- Meghan Riddell
- Laboratory for Cell Polarity and Organogenesis, Max Planck Institute for Heart and Lung Research
- Akiko Nakayama
- Department of Pharmacology, Max Planck Institute for Heart and Lung Research
- Takao Hikita
- Laboratory for Cell Polarity and Organogenesis, Max Planck Institute for Heart and Lung Research
- Fatemeh Mirzapourshafiyi
- Laboratory for Cell Polarity and Organogenesis, Max Planck Institute for Heart and Lung Research
- Takuji Kawamura
- Laboratory for Cell Polarity and Organogenesis, Max Planck Institute for Heart and Lung Research
- Ayesha Pasha
- Laboratory for Cell Polarity and Organogenesis, Max Planck Institute for Heart and Lung Research
- Mengnan Li
- Laboratory for Cell Polarity and Organogenesis, Max Planck Institute for Heart and Lung Research
- Mikio Masuzawa
- Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University
- Mario Looso
- Bioinformatics Service Group, Max Planck Institute for Heart and Lung Research
- Tim Steinbacher
- Institute-Associated Research Group: Cell Adhesion and Cell Polarity, Institute of Medical Biochemistry, ZMBE, University of Münster
- Klaus Ebnet
- Institute-Associated Research Group: Cell Adhesion and Cell Polarity, Institute of Medical Biochemistry, ZMBE, University of Münster
- Michael Potente
- Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research
- Tomonori Hirose
- Department of Molecular Biology, Yokohama City University School of Medicine
- Shigeo Ohno
- Department of Molecular Biology, Yokohama City University School of Medicine
- Ingrid Fleming
- Institute for Vascular Signaling, Centre for Molecular Medicine, Goethe University
- Stefan Gattenlöhner
- Institute of Pathology, University Hospital, Justus-Liebig-University Giessen
- Phyu P. Aung
- Department of Pathology University of Texas, M.D. Anderson Cancer Center
- Thuy Phung
- Department of Pathology & Immunology, Baylor College of Medicine, Texas Children’s Hospital
- Osamu Yamasaki
- Department of Dermatology, Okayama University, School of Medicine
- Teruki Yanagi
- Department of Dermatology, Hokkaido University Graduate School of Medicine
- Hiroshi Umemura
- Department of Dermatology, Okayama University, School of Medicine
- Masanori Nakayama
- Laboratory for Cell Polarity and Organogenesis, Max Planck Institute for Heart and Lung Research
- DOI
- https://doi.org/10.1038/s41467-018-07739-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
The cell polarity regulator aPKC is associated with cell proliferation but the precise mechanism are unknown. Here, the authors find that aPKC lambda phosphorylates the FoxO1 transcription factor, a gatekeeper of endothelial growth, during both angiogenesis and angiosarcomas.
