Journal of Pain Research (Mar 2024)
The New Orientation of Postoperative Analgesia: Remote Ischemic Preconditioning
Abstract
Yunyu Xiao, Shaofeng Zhang, Qiusheng Ren Department of Anesthesiology, Hangzhou Ninth People’s Hospital, Hangzhou, Zhejiang, 311225, People’s Republic of ChinaCorrespondence: Qiusheng Ren, Department of Anesthesiology, Hangzhou Ninth People’s Hospital, No. 298, Yilong Road, Hangzhou, Zhejiang, 311225, People’s Republic of China, Tel +86 15372085337, Email [email protected] of Review: Postoperative analgesia is currently a significant topic in anesthesiology. Currently, the predominant approach for achieving multimodal analgesia involves the utilization of pharmacotherapy and regional anesthesia procedures. The primary objectives of this approach are to mitigate postoperative pain, enhance patient satisfaction, and diminish overall opioid usage. Nevertheless, there is a scarcity of research on the use of remote ischemia preconditioning aimed at mitigating postoperative pain.Recent Findings: Transient stoppage of blood flow to an organ has been found to elicit remote ischemia preconditioning (RIPC), which serves as a potent intrinsic mechanism for protecting numerous organs. In addition to its established role in protecting against reperfusion injury, RIPC has recently been identified as having potential benefits in the context of postoperative analgesia.Summary: In addition to traditional perioperative analgesia, RIPC provides perioperative analgesia and organ protection.Keywords: postoperative pain, remote ischemic preconditioning, inflammation, opioids
