Laminin regulates PDGFRβ+ cell stemness and muscle development

Yao Yao; Erin H. Norris; Christopher E. Mason; Sidney Strickland

doi:10.1038/ncomms11415

Nature Communications (May 2016)

Laminin regulates PDGFRβ+ cell stemness and muscle development

Yao Yao,
Erin H. Norris,
Christopher E. Mason,
Sidney Strickland

Affiliations

Yao Yao: Laboratory of Neurobiology and Genetics, The Rockefeller University
Erin H. Norris: Laboratory of Neurobiology and Genetics, The Rockefeller University
Christopher E. Mason: Department of Physiology and Biophysics, Weill Cornell Medical College
Sidney Strickland: Laboratory of Neurobiology and Genetics, The Rockefeller University

DOI: https://doi.org/10.1038/ncomms11415
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Muscle PDGFRβ+ cells are interstitial stem/progenitor cells with myogenic potential. Here, Yao et al. show that PDGFRβ+cell-derived laminin actively regulates their proliferation, differentiation and fate determination.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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