Which Markers Play a Role in Diabetic Polyneuropathy and Neuropathic Pain?

Abstract

Objective:In diabetes mellitus (DM) patients, in the development of neuropathy and pain, uric acid (UA), C-reactive protein (CRP), γ-glutamyltransferase (GGT), erythrocyte sedimentation rate (ESR), and fibrinogen increased levels may affect the being of neuropathy by increasing oxidative stress through mechanisms related to inflammation and vascular impairment. In the study, we intended to compare serum UA, GGT, CRP, ESR, and fibrinogen levels in type 2 DM patients, with and without polyneuropathy.Method:Ninety-six type 2 DM patients and 24 participants were included in the study. Physical examinations, neuropathic pain scales, laboratory tests (UA, GGT, CRP, ESR, and fibrinogen levels), and electroneuromyography were evaluated.Results:Ninety-six type 2 DM patients and 24 healthy persons were included in the study as the study and control groups. Diabetic polyneuropathy (DPN) patients with neuropathic pain showed that CRP and low-density lipoprotein cholesterol levels were statistically significantly higher. No statistically significant difference was found between the groups in terms of UA, GGT, CRP, and fibrinogen levels.Conclusion:Increased CRP levels in DPN patients with neuropathic pain may reflect the inflammatory mechanisms involved in the pathogenesis of pain associated with DPN.

Keywords

• crp
• diabetes mellitus
• diabetic neuropathic pain
• diabetic peripheral neuropathy
• uric acid