Nature Communications (Aug 2019)
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion
- Mike R. Wilson,
- Jake J. Reske,
- Jeanne Holladay,
- Genna E. Wilber,
- Mary Rhodes,
- Julie Koeman,
- Marie Adams,
- Ben Johnson,
- Ren-Wei Su,
- Niraj R. Joshi,
- Amanda L. Patterson,
- Hui Shen,
- Richard E. Leach,
- Jose M. Teixeira,
- Asgerally T. Fazleabas,
- Ronald L. Chandler
Affiliations
- Mike R. Wilson
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- Jake J. Reske
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- Jeanne Holladay
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- Genna E. Wilber
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- Mary Rhodes
- Genomics Core Facility, Van Andel Research Institute
- Julie Koeman
- Genomics Core Facility, Van Andel Research Institute
- Marie Adams
- Genomics Core Facility, Van Andel Research Institute
- Ben Johnson
- Bioinformatics and Biostatistics Core Facility, Van Andel Research Institute
- Ren-Wei Su
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- Niraj R. Joshi
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- Amanda L. Patterson
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- Hui Shen
- Center for Epigenetics, Van Andel Research Institute
- Richard E. Leach
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- Jose M. Teixeira
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- Asgerally T. Fazleabas
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- Ronald L. Chandler
- Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University
- DOI
- https://doi.org/10.1038/s41467-019-11403-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
PIK3CA mutations and ARID1A loss co-exist in endometrial neoplasms. Here, the authors show that these co-mutations drive gene expression profiles correlated with differential chromatin accessibility and ARID1A binding in the endometrial epithelium, resulting in partial EMT and myometrial invasion.
