Nature Communications (Sep 2019)

Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy

  • Sung Pil Hong,
  • Thalia E. Chan,
  • Ylenia Lombardo,
  • Giacomo Corleone,
  • Nicole Rotmensz,
  • Sara Bravaccini,
  • Andrea Rocca,
  • Giancarlo Pruneri,
  • Kirsten R. McEwen,
  • R. Charles Coombes,
  • Iros Barozzi,
  • Luca Magnani

DOI
https://doi.org/10.1038/s41467-019-11721-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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The development of resistance to endocrine therapy is a significant, clinical problem in breast cancer. Here, the authors identify a rare subpopulation of cells that drive resistance following transcriptional reprogramming.