Visual prognosis based staging for retinal capillary hemangioma

Abstract

Purpose. To analyze the literature to determine the visual prognosis of eyes affected by retinal angiomatosis of Von-Hippel Lindau disease (VHL). Study Type. Retrospective literature analysis. Methods. Medline and PubMed searches were performed for publications on retinal capillary hemangioma (CRH). Data was collected on patient age of presentation, CRH laterality, location, treatment, and progression. Statistical analyses using Pearson Chi-Square test, likelihood ratio, and Fischer’s exact tests were performed for the effect of these characteristics on visual acuity outcomes. Results. Vision outcomes need to be based on current technology to be clinically relevant. Therefore, only significant publications from 1960 to 2019 were included. Of these, 5 clinical case series included, a total of 427 cases. Of these 69.4 % (58–94.1 %) cases were unilateral CRH, 30.6 % (5.9–42 %) were bilateral, 18.1 % (10.9–23.5 %) were juxtapapillary in location. Major factors affecting visual acuity were age at onset (p = 0.03), location (p < 0.0001) and multifocality (p = 0.0005). Of interest, CRH-related vision loss was independent of the presence of VHL disease (p = 0.157). Conclusion. In this study, age at onset, location, multifocality of CRH were the most important predictors of vision loss, which were used to create a vision-outcome based classification system. This information can be used to counsel patients and for informed consent.

Keywords

• острота зрения
• капилляр
• сетчатка
• зрение
• прогноз
• болезнь гиппеля — линдау