Nature Communications (Feb 2022)
SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load
- Tobias Mourier,
- Muhammad Shuaib,
- Sharif Hala,
- Sara Mfarrej,
- Fadwa Alofi,
- Raeece Naeem,
- Afrah Alsomali,
- David Jorgensen,
- Amit Kumar Subudhi,
- Fathia Ben Rached,
- Qingtian Guan,
- Rahul P. Salunke,
- Amanda Ooi,
- Luke Esau,
- Olga Douvropoulou,
- Raushan Nugmanova,
- Sadhasivam Perumal,
- Huoming Zhang,
- Issaac Rajan,
- Awad Al-Omari,
- Samer Salih,
- Abbas Shamsan,
- Abbas Al Mutair,
- Jumana Taha,
- Abdulaziz Alahmadi,
- Nashwa Khotani,
- Abdelrahman Alhamss,
- Ahmed Mahmoud,
- Khaled Alquthami,
- Abdullah Dageeg,
- Asim Khogeer,
- Anwar M. Hashem,
- Paula Moraga,
- Eric Volz,
- Naif Almontashiri,
- Arnab Pain
Affiliations
- Tobias Mourier
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Muhammad Shuaib
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Sharif Hala
- Infectious Disease Research Department, King Abdullah International Medical Research Centre, Ministry of National Guard Health Affairs
- Sara Mfarrej
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Fadwa Alofi
- Infectious Diseases Department, King Fahad Hospital
- Raeece Naeem
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Afrah Alsomali
- Infectious Diseases Department, King Abdullah Medical Complex
- David Jorgensen
- School of Public Health, Faculty of Medicine, Imperial College, Norfolk Place, St Mary’s Campus
- Amit Kumar Subudhi
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Fathia Ben Rached
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Qingtian Guan
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Rahul P. Salunke
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Amanda Ooi
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Luke Esau
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Olga Douvropoulou
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Raushan Nugmanova
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Sadhasivam Perumal
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Huoming Zhang
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Issaac Rajan
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- Awad Al-Omari
- Dr. Suliman Al-Habib Medical Group
- Samer Salih
- Dr. Suliman Al-Habib Medical Group
- Abbas Shamsan
- Dr. Suliman Al-Habib Medical Group
- Abbas Al Mutair
- Dr. Suliman Al-Habib Medical Group
- Jumana Taha
- Department of Neuroscience, King Faisal Specialist Hospital and Research Center
- Abdulaziz Alahmadi
- Department of Preventive Medicine, Ministry of National Guard - Health Affairs
- Nashwa Khotani
- Infectious Diseases Medical Department, Al Noor Specialist Hospital Makkah
- Abdelrahman Alhamss
- Gastroenterology Department, King Abdul Aziz Hospital Makkah
- Ahmed Mahmoud
- College of Applied Medical Sciences, Taibah University
- Khaled Alquthami
- Infectious Diseases Medical Department, Al Noor Specialist Hospital Makkah
- Abdullah Dageeg
- Department of Medicine, King Abdulaziz University Jeddah
- Asim Khogeer
- Plan and Research Department, General Directorate of Health Affairs Makkah Region
- Anwar M. Hashem
- Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University
- Paula Moraga
- King Abdullah University of Science and Technology (KAUST), Computer, Electrical and Mathematical Science and Engineering Division (CEMSE)
- Eric Volz
- School of Public Health, Faculty of Medicine, Imperial College, Norfolk Place, St Mary’s Campus
- Naif Almontashiri
- College of Applied Medical Sciences, Taibah University
- Arnab Pain
- King Abdullah University of Science and Technology (KAUST), Pathogen Genomics Laboratory, Biological and Environmental Science and Engineering (BESE)
- DOI
- https://doi.org/10.1038/s41467-022-28287-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
In this study, the authors sequence 892 SARS-CoV-2 genomes from Saudi Arabia and describe population dynamics and importations into the country. They identify a nucleocapsid protein mutation associated with increased viral load and host interactions and characterise its role through biochemical analyses.
