Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane

Abstract

An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl 3-oxo-7a,12a-diacetoxy-5b-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 mg/mL; IC50 (W2) = 0.29 mg/mL).

Keywords

• tetraoxane
• malaria
• peroxide
• steroid
• intramolecular