Stereodivergent synthesis of chiral succinimides via Rh-catalyzed asymmetric transfer hydrogenation

Fangyuan Wang; Zongpeng Zhang; Yu Chen; Virginie Ratovelomanana-Vidal; Peiyuan Yu; Gen-Qiang Chen; Xumu Zhang

doi:10.1038/s41467-022-35124-5

Nature Communications (Dec 2022)

Stereodivergent synthesis of chiral succinimides via Rh-catalyzed asymmetric transfer hydrogenation

Fangyuan Wang,
Zongpeng Zhang,
Yu Chen,
Virginie Ratovelomanana-Vidal,
Peiyuan Yu,
Gen-Qiang Chen,
Xumu Zhang

Affiliations

Fangyuan Wang: Department of Chemistry, Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
Zongpeng Zhang: Department of Chemistry, Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
Yu Chen: Department of Chemistry, Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
Virginie Ratovelomanana-Vidal: PSL University, Chimie ParisTech, CNRS, Institute1 of Chemistry for Life and Health Sciences, CSB2D team
Peiyuan Yu: Department of Chemistry, Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
Gen-Qiang Chen: Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Xumu Zhang: Department of Chemistry, Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-35124-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Chiral succinimides are ubiquitous in bioactive compounds. Here, authors report a stereodivergent method for accessing 3,4-disubstituted succinimides, and the origin of stereoselectivity is elucidated by experimental and theoretical investigations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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