Incomplete prophage tolerance by type III-A CRISPR-Cas systems reduces the fitness of lysogenic hosts

Gregory W. Goldberg; Elizabeth A. McMillan; Andrew Varble; Joshua W. Modell; Poulami Samai; Wenyan Jiang; Luciano A. Marraffini

doi:10.1038/s41467-017-02557-2

Nature Communications (Jan 2018)

Incomplete prophage tolerance by type III-A CRISPR-Cas systems reduces the fitness of lysogenic hosts

Gregory W. Goldberg,
Elizabeth A. McMillan,
Andrew Varble,
Joshua W. Modell,
Poulami Samai,
Wenyan Jiang,
Luciano A. Marraffini

Affiliations

Gregory W. Goldberg: Laboratory of Bacteriology, The Rockefeller University
Elizabeth A. McMillan: Laboratory of Systems Cancer Biology, The Rockefeller University
Andrew Varble: Laboratory of Bacteriology, The Rockefeller University
Joshua W. Modell: Laboratory of Bacteriology, The Rockefeller University
Poulami Samai: Laboratory of Bacteriology, The Rockefeller University
Wenyan Jiang: Laboratory of Bacteriology, The Rockefeller University
Luciano A. Marraffini: Laboratory of Bacteriology, The Rockefeller University

DOI: https://doi.org/10.1038/s41467-017-02557-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

CRISPR-Cas systems, such as type III-A CRISPR-Cas, provide an immune mechanism for prokaryotic hosts to resist parasites, including phages. Here, the authors show that maintenance of conditionally tolerant type III-A systems can affect the fitness of Staphylococcus aureus lysogens.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal