Breast Cancer Research (Jan 2020)
Nutrient-wide association study of 92 foods and nutrients and breast cancer risk
- Alicia K. Heath,
- David C. Muller,
- Piet A. van den Brandt,
- Nikos Papadimitriou,
- Elena Critselis,
- Marc Gunter,
- Paolo Vineis,
- Elisabete Weiderpass,
- Guy Fagherazzi,
- Heiner Boeing,
- Pietro Ferrari,
- Anja Olsen,
- Anne Tjønneland,
- Patrick Arveux,
- Marie-Christine Boutron-Ruault,
- Francesca Romana Mancini,
- Tilman Kühn,
- Renée Turzanski-Fortner,
- Matthias B. Schulze,
- Anna Karakatsani,
- Paschalis Thriskos,
- Antonia Trichopoulou,
- Giovanna Masala,
- Paolo Contiero,
- Fulvio Ricceri,
- Salvatore Panico,
- Bas Bueno-de-Mesquita,
- Marije F. Bakker,
- Carla H. van Gils,
- Karina Standahl Olsen,
- Guri Skeie,
- Cristina Lasheras,
- Antonio Agudo,
- Miguel Rodríguez-Barranco,
- Maria-José Sánchez,
- Pilar Amiano,
- María-Dolores Chirlaque,
- Aurelio Barricarte,
- Isabel Drake,
- Ulrika Ericson,
- Ingegerd Johansson,
- Anna Winkvist,
- Tim Key,
- Heinz Freisling,
- Mathilde His,
- Inge Huybrechts,
- Sofia Christakoudi,
- Merete Ellingjord-Dale,
- Elio Riboli,
- Konstantinos K. Tsilidis,
- Ioanna Tzoulaki
Affiliations
- Alicia K. Heath
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- David C. Muller
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Piet A. van den Brandt
- Department of Epidemiology, Maastricht University Medical Centre
- Nikos Papadimitriou
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine
- Elena Critselis
- Proteomics Facility, Center for Systems Biology, Biomedical Research Foundation of the Academy of Athens
- Marc Gunter
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Paolo Vineis
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Elisabete Weiderpass
- International Agency for Research on Cancer, World Health Organization
- Guy Fagherazzi
- Center of Research in Epidemiology and Population Health (CESP), Inserm U1018, Paris-South Paris-Saclay University, Gustave Roussy
- Heiner Boeing
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
- Pietro Ferrari
- Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization
- Anja Olsen
- Danish Cancer Society Research Center
- Anne Tjønneland
- Danish Cancer Society Research Center
- Patrick Arveux
- Center of Research in Epidemiology and Population Health (CESP), Inserm U1018, Paris-South Paris-Saclay University, Gustave Roussy
- Marie-Christine Boutron-Ruault
- Center of Research in Epidemiology and Population Health (CESP), Inserm U1018, Paris-South Paris-Saclay University, Gustave Roussy
- Francesca Romana Mancini
- Center of Research in Epidemiology and Population Health (CESP), Inserm U1018, Paris-South Paris-Saclay University, Gustave Roussy
- Tilman Kühn
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Renée Turzanski-Fortner
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Matthias B. Schulze
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
- Anna Karakatsani
- Hellenic Health Foundation
- Paschalis Thriskos
- Hellenic Health Foundation
- Antonia Trichopoulou
- Hellenic Health Foundation
- Giovanna Masala
- Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
- Paolo Contiero
- Environmental Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
- Fulvio Ricceri
- Department of Clinical and Biological Sciences, University of Turin
- Salvatore Panico
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University
- Bas Bueno-de-Mesquita
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Marije F. Bakker
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University
- Carla H. van Gils
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University
- Karina Standahl Olsen
- Department of Community Medicine, UiT The Arctic University of Norway
- Guri Skeie
- Department of Community Medicine, UiT The Arctic University of Norway
- Cristina Lasheras
- Functional Biology Department, School of Medicine, University of Oviedo
- Antonio Agudo
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology - ICO, Group of Research on Nutrition and Cancer, Bellvitge Biomedical Research Institute – IDIBELL, L’Hospitalet of Llobregat
- Miguel Rodríguez-Barranco
- Andalusian School of Public Health (EASP)
- Maria-José Sánchez
- Andalusian School of Public Health (EASP)
- Pilar Amiano
- CIBER of Epidemiology and Public Health (CIBERESP)
- María-Dolores Chirlaque
- CIBER of Epidemiology and Public Health (CIBERESP)
- Aurelio Barricarte
- CIBER of Epidemiology and Public Health (CIBERESP)
- Isabel Drake
- Department of Clinical Sciences in Malmö, Lund University
- Ulrika Ericson
- Department of Clinical Sciences in Malmö, Lund University
- Ingegerd Johansson
- Department of Odontology, Umeå University
- Anna Winkvist
- Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg
- Tim Key
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford
- Heinz Freisling
- Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization
- Mathilde His
- Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization
- Inge Huybrechts
- Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization
- Sofia Christakoudi
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Merete Ellingjord-Dale
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Elio Riboli
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Konstantinos K. Tsilidis
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Ioanna Tzoulaki
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- DOI
- https://doi.org/10.1186/s13058-019-1244-7
- Journal volume & issue
-
Vol. 22,
no. 1
pp. 1 – 12
Abstract
Abstract Background Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. Methods Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). Results Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03–1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03–1.06 and 1.04, 95% CI 1.02–1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94–0.98; 0.96, 95% CI 0.94–0.99; and 0.96, 95% CI 0.95–0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. Conclusions Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.
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