GALECTIN 3 AND ALDOSTERONE IN PATIENTS WITH ATRIAL FIBRILLATION AND METABOLIC SYNDROME

Abstract

Aim. To study the levels of galectin 3 and aldostrone in blood serum of metabolic syndrome (MS) patients and atrial fibrillation (AF) for their importance evaluation. Material and methods. Totally 100 patients with MS (IDF, 2005) studied, of those 50 with AF: 28 with paroxysmal and 22 with persistent types. Controls were 50 almost healthy persons without cardiovascular pathology and metabolic disorders. Levels of galectin 3 and aldosterone in serum were measured by ELISA. All participants also underwent anthropometry, lipid profile and fasting glycemia measurements, transthoracal echocardiography.Results. Galectin 3 level in MS and AF patients' serum was higher than in MS without AF and than in healthy persons (0,72 [0,44;1,36], 0,44 [0,42;1,22] and 0,32[0,28;0,42]ng/ml, resp.; p<0,01). Level of aldosterone in serum of MSwith AF patients was also 2 times higher than in healthy persons (202,2±82,4 and 98,4±51,2 pg/ml, p<0,001) and higher than in MS without AF (202,2±82,4 and 148,3±73,3 pg/ml, p<0,001). In patients with persisting AF there was higher level of galectine 3 and aldosterone comparing to those with paroxysmal. We found positive correlation in aldosterone levels and galectin 3 in serum (r=0,521, p<0,001).Conclusion. Markers of myocardial fibrosis galectin 3 and aldosterone in serum of atrial fibrillation patients with metabolic syndrome were higher than in metabolic syndrome without that type of arrhythmia and than in healthy persons. In persisting type of atrial fibrillation the level of galectin3 was higher than in paroxysmal type.

Keywords

• galectin 3
• aldosterone
• fibrosis markers
• metabolic syndrome
• atrial fibrillation.