Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies

Marco Giardiello; Neill J. Liptrott; Tom O. McDonald; Darren Moss; Marco Siccardi; Phil Martin; Darren Smith; Rohan Gurjar; Steve P. Rannard; Andrew Owen

doi:10.1038/ncomms13184

Nature Communications (Oct 2016)

Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies

Marco Giardiello,
Neill J. Liptrott,
Tom O. McDonald,
Darren Moss,
Marco Siccardi,
Phil Martin,
Darren Smith,
Rohan Gurjar,
Steve P. Rannard,
Andrew Owen

Affiliations

Marco Giardiello: Department of Chemistry, University of Liverpool
Neill J. Liptrott: Department of Molecular and Clinical Pharmacology, University of Liverpool
Tom O. McDonald: Department of Chemistry, University of Liverpool
Darren Moss: Department of Molecular and Clinical Pharmacology, University of Liverpool
Marco Siccardi: Department of Molecular and Clinical Pharmacology, University of Liverpool
Phil Martin: Department of Molecular and Clinical Pharmacology, University of Liverpool
Darren Smith: Department of Molecular and Clinical Pharmacology, University of Liverpool
Rohan Gurjar: Department of Molecular and Clinical Pharmacology, University of Liverpool
Steve P. Rannard: Department of Chemistry, University of Liverpool
Andrew Owen: Department of Molecular and Clinical Pharmacology, University of Liverpool

DOI: https://doi.org/10.1038/ncomms13184
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

Nanomedicine efficacy in a clinical setting depends on the pharmacological properties of the therapeutic nanoparticles. Here, the authors exemplify an accelerated translational strategy from small-scale screening to clinical scale-up for an orally-dosed aqueous paediatric HIV nanomedicine.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal