Features of a clinical course of immune cytopenias with a high titer of autoantibodies to the thyroid

Abstract

Aim. To ascertain the role of high antibodies (Ab) titers to microsomal antigen (MA) of the thyroid in clinical manifestations of cytopenic syndromes. Material and methods. Clinical data are presented on 144 patients with depressed hemopoiesis having different levels of thyroid Aab. Results. When the titer was significantly elevated (41% patients with immune cytopenias), hematological malignancies run with recurrences, remission is rare. Treatment of the thyroid pathology improves hematological indices in some cases though does not reduce titers of Ab thyroid MA. Conclusion. Detection of autoimmune pathology of the thyroid is necessary not only for specification of the concurrent process diagnosis but also for initiation of adequate combined treatment.

Keywords

• autoimmune thyroiditis
• antibodies to thyroid microsomal antigen
• antibodies to thyroperoxidase
• autoimmune hemolytic anemia
• idiopathic thrombocytopenic purpura
• cytopenia