Frontiers in Neurology (Mar 2023)

Headache in long COVID as disabling condition: A clinical approach

  • Arthur Nascimento Rodrigues,
  • Apio Ricardo Nazareth Dias,
  • Alna Carolina Mendes Paranhos,
  • Alna Carolina Mendes Paranhos,
  • Camilla Costa Silva,
  • Thalita da Rocha Bastos,
  • Bárbara Barros de Brito,
  • Nívia Monteiro da Silva,
  • Emanuel de Jesus Soares de Sousa,
  • Juarez Antônio Simões Quaresma,
  • Juarez Antônio Simões Quaresma,
  • Juarez Antônio Simões Quaresma,
  • Luiz Fábio Magno Falcão,
  • Luiz Fábio Magno Falcão

DOI
https://doi.org/10.3389/fneur.2023.1149294
Journal volume & issue
Vol. 14

Abstract

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Background and purposeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can exacerbate previous headache disorders or change the type of pain experienced from headaches. This study aimed to investigate the clinical features of Long COVID headaches.MethodThis was a cross-sectional, descriptive, and analytical observational study that included 102 patients (with previous headache, n = 50; without previous headache, n = 52) with long COVID and headache complaints. The Migraine Disability Assessment Test and Visual Analog Pain Scale were used to collect participants' headache data according to a standardized protocol.ResultsThe patients in this study who reported experiencing headaches before COVID-19 had longer headache duration in the long COVID phase than that in the pre-long COVID phase (p = 0.031), exhibited partial improvement in headache symptoms with analgesics (p = 0.045), and had a duration of long COVID of <1 year (p = 0.030). Patients with moderate or severe disability and those classified as having severe headaches in the long COVID phase were highly likely to develop chronic headaches. Hospital admission [odds ratio (OR) = 3.0082; 95% confidence interval (95% CI): 1.10–8.26], back pain (OR = 4.0017; 95% CI: 1.13–14.17), insomnia (OR = 3.1339; 95% CI: 1.39–7.06), and paraesthesia (OR = 2.7600; 95% CI: 1.20–6.33) were associated with headache in these patients.ConclusionHeadache is a disabling condition in patients with long COVID-19, exacerbating the conditions of those with headaches prior to contracting COVID-19.

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