Nature Communications (May 2016)
ISG15 deficiency and increased viral resistance in humans but not mice
- Scott D. Speer,
- Zhi Li,
- Sofija Buta,
- Béatrice Payelle-Brogard,
- Li Qian,
- Frederic Vigant,
- Erminia Rubino,
- Thomas J. Gardner,
- Tim Wedeking,
- Mark Hermann,
- James Duehr,
- Ozden Sanal,
- Ilhan Tezcan,
- Nahal Mansouri,
- Payam Tabarsi,
- Davood Mansouri,
- Véronique Francois-Newton,
- Coralie F. Daussy,
- Marisela R. Rodriguez,
- Deborah J. Lenschow,
- Alexander N. Freiberg,
- Domenico Tortorella,
- Jacob Piehler,
- Benhur Lee,
- Adolfo García-Sastre,
- Sandra Pellegrini,
- Dusan Bogunovic
Affiliations
- Scott D. Speer
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Zhi Li
- Institut Pasteur, Cytokine Signalling Unit
- Sofija Buta
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Béatrice Payelle-Brogard
- Institut Pasteur, Cytokine Signalling Unit
- Li Qian
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Frederic Vigant
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Erminia Rubino
- Institut Pasteur, Cytokine Signalling Unit
- Thomas J. Gardner
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Tim Wedeking
- Department of Biology, University of Osnabrück
- Mark Hermann
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- James Duehr
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Ozden Sanal
- Immunology Division, Hacettepe University, Ihsan Dogramaci Children’s Hospital
- Ilhan Tezcan
- Immunology Division, Hacettepe University, Ihsan Dogramaci Children’s Hospital
- Nahal Mansouri
- Division of Infectious Diseases and Clinical Immunology, Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences
- Payam Tabarsi
- Division of Infectious Diseases and Clinical Immunology, Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences
- Davood Mansouri
- Division of Infectious Diseases and Clinical Immunology, Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences
- Véronique Francois-Newton
- Institut Pasteur, Cytokine Signalling Unit
- Coralie F. Daussy
- Institut Pasteur, Cytokine Signalling Unit
- Marisela R. Rodriguez
- Department of Medicine and Department of Pathology and Immunology, Washington University School of Medicine
- Deborah J. Lenschow
- Department of Medicine and Department of Pathology and Immunology, Washington University School of Medicine
- Alexander N. Freiberg
- Department of Pathology, University of Texas Medical Branch
- Domenico Tortorella
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Jacob Piehler
- Department of Biology, University of Osnabrück
- Benhur Lee
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Adolfo García-Sastre
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Sandra Pellegrini
- Institut Pasteur, Cytokine Signalling Unit
- Dusan Bogunovic
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/ncomms11496
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
ISG15 is a ubiquitin-like protein which has important immune-related functions in mice and humans. Here the authors demonstrate that, unlike in mice, human ISG15 stabilizes UPS18 and that ISG15-deficient human cells are more resistant to viral infection.
