EXPRESSION LEVELS OF SOME ADHESION MOLECULES IN THE INTACT AND UV-IRRADIATED Т-LYMPHOCYTES FROM HUMAN BLOOD

Abstract

Abstract. While employing an enzyme linked immunosorbent assay, it was shown that UV-sensitivity is different for various adhesion molecules (CD2, CD11a and CD29) at the membranes of T-lymphocytes. Relative photoresistance of CD2 and CD11a antigens to UV irradiation was established at the doses range of 151 to 906 J/m2, a large dose of UV-iradiation (1359 J/m2) exerted a suppressive effect upon their expression level. An immunomodulatory action of UV-radiation was revealed upon expression of CD29 transmembrane protein by T-cells. A dependence between amino acid structure and photosensitivity of CD2, CD11a and CD29 antigens of T lymphocytes is analyzed and discussed.

Keywords

• adhesion molecules
• expression
• photosensitivity
• elisa