An updated review of epidemiological characteristics, immune escape, and therapeutic advances of SARS-CoV-2 Omicron XBB.1.5 and other mutants

Zongming Liu; Zongming Liu; Jiaxuan Li; Shanshan Pei; Shanshan Pei; Ying Lu; Chaonan Li; Jiajie Zhu; Ruyi Chen; Di Wang; Jingbo Sun; Keda Chen

doi:10.3389/fcimb.2023.1297078

Frontiers in Cellular and Infection Microbiology (Dec 2023)

An updated review of epidemiological characteristics, immune escape, and therapeutic advances of SARS-CoV-2 Omicron XBB.1.5 and other mutants

Zongming Liu,
Zongming Liu,
Jiaxuan Li,
Shanshan Pei,
Shanshan Pei,
Ying Lu,
Chaonan Li,
Jiajie Zhu,
Ruyi Chen,
Di Wang,
Jingbo Sun,
Keda Chen

Affiliations

Zongming Liu: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China
Zongming Liu: Sir Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Jiaxuan Li: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China
Shanshan Pei: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China
Shanshan Pei: School of Pharmacy, Beihua University, Jilin, China
Ying Lu: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China
Chaonan Li: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China
Jiajie Zhu: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China
Ruyi Chen: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China
Di Wang: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China
Jingbo Sun: School of Pharmacy, Beihua University, Jilin, China
Keda Chen: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China

DOI: https://doi.org/10.3389/fcimb.2023.1297078
Journal volume & issue: Vol. 13

Abstract

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The rapid evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to the emergence of new variants with different genetic profiles, with important implications for public health. The continued emergence of new variants with unique genetic features and potential changes in biological properties poses significant challenges to public health strategies, vaccine development, and therapeutic interventions. Omicron variants have attracted particular attention due to their rapid spread and numerous mutations in key viral proteins. This review aims to provide an updated and comprehensive assessment of the epidemiological characteristics, immune escape potential, and therapeutic advances of the SARS-CoV-2 Omicron XBB.1.5 variant, as well as other variants.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

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