Nature Communications (May 2019)
Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus
- Christopher A. Odhams,
- Amy L. Roberts,
- Susan K. Vester,
- Carolina S. T. Duarte,
- Charlie T. Beales,
- Alexander J. Clarke,
- Sonja Lindinger,
- Samuel J. Daffern,
- Antonino Zito,
- Lingyan Chen,
- Leonardo L. Jones,
- Lora Boteva,
- David L. Morris,
- Kerrin S. Small,
- Michelle M. A. Fernando,
- Deborah S. Cunninghame Graham,
- Timothy J. Vyse
Affiliations
- Christopher A. Odhams
- Department of Medical & Molecular Genetics, King’s College London
- Amy L. Roberts
- Department of Medical & Molecular Genetics, King’s College London
- Susan K. Vester
- Department of Medical & Molecular Genetics, King’s College London
- Carolina S. T. Duarte
- Department of Medical & Molecular Genetics, King’s College London
- Charlie T. Beales
- Department of Medical & Molecular Genetics, King’s College London
- Alexander J. Clarke
- Kennedy Institute of Rheumatology, University of Oxford
- Sonja Lindinger
- Department of Medical & Molecular Genetics, King’s College London
- Samuel J. Daffern
- Department of Medical & Molecular Genetics, King’s College London
- Antonino Zito
- Department of Twin Research & Genetic Epidemiology, King’s College London
- Lingyan Chen
- Department of Medical & Molecular Genetics, King’s College London
- Leonardo L. Jones
- Department of Medical & Molecular Genetics, King’s College London
- Lora Boteva
- Department of Medical & Molecular Genetics, King’s College London
- David L. Morris
- Department of Medical & Molecular Genetics, King’s College London
- Kerrin S. Small
- Department of Twin Research & Genetic Epidemiology, King’s College London
- Michelle M. A. Fernando
- Department of Medical & Molecular Genetics, King’s College London
- Deborah S. Cunninghame Graham
- Department of Medical & Molecular Genetics, King’s College London
- Timothy J. Vyse
- Department of Medical & Molecular Genetics, King’s College London
- DOI
- https://doi.org/10.1038/s41467-019-10106-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Systemic lupus erythematosus (SLE) shows a striking bias towards higher prevalence in females. Here, the authors perform fine-mapping of an SLE-associated locus at Xp21.2 and characterise a candidate gene, CXorf21, as IFN-responsive in immune cells that shows sexually dimorphic expression.
