Nature Communications (Apr 2020)
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development
- Tatiana Popovitchenko,
- Yongkyu Park,
- Nicholas F. Page,
- Xiaobing Luo,
- Zeljka Krsnik,
- Yuan Liu,
- Iva Salamon,
- Jessica D. Stephenson,
- Matthew L. Kraushar,
- Nicole L. Volk,
- Sejal M. Patel,
- H. R. Sagara Wijeratne,
- Diana Li,
- Kandarp S. Suthar,
- Aaron Wach,
- Miao Sun,
- Sebastian J. Arnold,
- Wado Akamatsu,
- Hideyuki Okano,
- Luc Paillard,
- Huaye Zhang,
- Steven Buyske,
- Ivica Kostovic,
- Silvia De Rubeis,
- Ronald P. Hart,
- Mladen-Roko Rasin
Affiliations
- Tatiana Popovitchenko
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Yongkyu Park
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Nicholas F. Page
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Xiaobing Luo
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Zeljka Krsnik
- Croatian Institute for Brain Research, Center of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb, School of Medicine
- Yuan Liu
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Iva Salamon
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Jessica D. Stephenson
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Matthew L. Kraushar
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Nicole L. Volk
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Sejal M. Patel
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- H. R. Sagara Wijeratne
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Diana Li
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Kandarp S. Suthar
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Aaron Wach
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Miao Sun
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Sebastian J. Arnold
- Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Signaling Research Centers BIOSS and CIBSS, University of Freiburg
- Wado Akamatsu
- Department of Physiology, Keio University School of Medicine
- Hideyuki Okano
- Department of Physiology, Keio University School of Medicine
- Luc Paillard
- Univ Rennes, CNRS, IGDR (Institut de génétique et développement de Rennes)-UMR 6290
- Huaye Zhang
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- Steven Buyske
- Department of Statistics, Rutgers University
- Ivica Kostovic
- Croatian Institute for Brain Research, Center of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb, School of Medicine
- Silvia De Rubeis
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Ronald P. Hart
- Department of Cell Biology and Neuroscience, Rutgers University
- Mladen-Roko Rasin
- Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School
- DOI
- https://doi.org/10.1038/s41467-020-15412-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 21
Abstract
Translational regulation of isoforms in the developing nervous system is not well understood. Here, the authors report translational de-repression of RNA binding protein isoforms at their 5′UTRs in the neocortex and show the neurodevelopmental risk of post-transcriptional dysregulation.
