Nature Communications (May 2020)

Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

  • Lei Miao,
  • Jiaqi Lin,
  • Yuxuan Huang,
  • Linxian Li,
  • Derfogail Delcassian,
  • Yifan Ge,
  • Yunhua Shi,
  • Daniel G. Anderson

DOI
https://doi.org/10.1038/s41467-020-16248-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Lipid-like nanoparticles have applications as non-viral delivery systems for mRNA. Here, the authors develop biodegradable lipids with improved clearance and reduced toxicity.