Nature Communications (Jun 2016)

Information recovery from low coverage whole-genome bisulfite sequencing

  • Emanuele Libertini,
  • Simon C. Heath,
  • Rifat A. Hamoudi,
  • Marta Gut,
  • Michael J. Ziller,
  • Agata Czyz,
  • Victor Ruotti,
  • Hendrik G. Stunnenberg,
  • Mattia Frontini,
  • Willem H. Ouwehand,
  • Alexander Meissner,
  • Ivo G. Gut,
  • Stephan Beck

DOI
https://doi.org/10.1038/ncomms11306
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 7

Abstract

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Here, Libertini and colleagues devise a computation tool that can analyze whole-genome bisulfite sequencing (WGBS) data to recover of ∼30% of the lost differential methylation position information. They use COMETgazer and COMETvintage to analyze 13 diffferent methylome data to demonstrate their performance.