Nature Communications (Jan 2022)
Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2
- Lamiaa El-Shennawy,
- Andrew D. Hoffmann,
- Nurmaa Khund Dashzeveg,
- Kathleen M. McAndrews,
- Paul J. Mehl,
- Daphne Cornish,
- Zihao Yu,
- Valerie L. Tokars,
- Vlad Nicolaescu,
- Anastasia Tomatsidou,
- Chengsheng Mao,
- Christopher J. Felicelli,
- Chia-Feng Tsai,
- Carolina Ostiguin,
- Yuzhi Jia,
- Lin Li,
- Kevin Furlong,
- Jan Wysocki,
- Xin Luo,
- Carolina F. Ruivo,
- Daniel Batlle,
- Thomas J. Hope,
- Yang Shen,
- Young Kwang Chae,
- Hui Zhang,
- Valerie S. LeBleu,
- Tujin Shi,
- Suchitra Swaminathan,
- Yuan Luo,
- Dominique Missiakas,
- Glenn C. Randall,
- Alexis R. Demonbreun,
- Michael G. Ison,
- Raghu Kalluri,
- Deyu Fang,
- Huiping Liu
Affiliations
- Lamiaa El-Shennawy
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Andrew D. Hoffmann
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Nurmaa Khund Dashzeveg
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Kathleen M. McAndrews
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Paul J. Mehl
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Daphne Cornish
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Zihao Yu
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Valerie L. Tokars
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Vlad Nicolaescu
- The University of Chicago Howard T. Ricketts Laboratory and Department of Microbiology
- Anastasia Tomatsidou
- The University of Chicago Howard T. Ricketts Laboratory and Department of Microbiology
- Chengsheng Mao
- Division of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Christopher J. Felicelli
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Chia-Feng Tsai
- Biological Sciences Division, Pacific Northwest National Laboratory
- Carolina Ostiguin
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Yuzhi Jia
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Lin Li
- Division of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Kevin Furlong
- The University of Chicago Howard T. Ricketts Laboratory and Department of Microbiology
- Jan Wysocki
- Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine
- Xin Luo
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Carolina F. Ruivo
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Daniel Batlle
- Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine
- Thomas J. Hope
- Department of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine
- Yang Shen
- Department of Electrical and Computer Engineering, TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University
- Young Kwang Chae
- Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine
- Hui Zhang
- Division of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Valerie S. LeBleu
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Tujin Shi
- Biological Sciences Division, Pacific Northwest National Laboratory
- Suchitra Swaminathan
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Yuan Luo
- Division of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Dominique Missiakas
- The University of Chicago Howard T. Ricketts Laboratory and Department of Microbiology
- Glenn C. Randall
- The University of Chicago Howard T. Ricketts Laboratory and Department of Microbiology
- Alexis R. Demonbreun
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- Michael G. Ison
- Division of Infectious Disease, Department of Medicine, Northwestern University Feinberg School of Medicine
- Raghu Kalluri
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Deyu Fang
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Huiping Liu
- Department of Pharmacology, Northwestern University Feinberg School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-27893-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
El-Shennawy et al. report that ACE2+ circulating extracellular vesicles (evACE2) are associated with COVID-19 severity and that evACE2 inhibits the infection of SARS-CoV-2 variants of concern at a higher efficacy than soluble ACE2.
