Blood Cancer Journal (May 2021)
High incidence of thromboembolism in patients with chronic GVHD: association with severity of GVHD and donor-recipient ABO blood group
- Najla El Jurdi,
- Heba Elhusseini,
- Joan Beckman,
- Todd E. DeFor,
- Grigori Okoev,
- John Rogosheske,
- Aleksandr Lazaryan,
- Kristen Weiler,
- Veronika Bachanova,
- Brian C. Betts,
- Bruce R. Blazar,
- Claudio G. Brunstein,
- Fiona He,
- Shernan G. Holtan,
- Murali Janakiram,
- Radhika Gangaraju,
- Joseph Maakaron,
- Margaret L. MacMillan,
- Armin Rashidi,
- Erica D. Warlick,
- Smita Bhatia,
- Gregory Vercellotti,
- Daniel J. Weisdorf,
- Mukta Arora
Affiliations
- Najla El Jurdi
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Heba Elhusseini
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Joan Beckman
- Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota
- Todd E. DeFor
- Biostatistics and Informatics, Clinical and Translational Science Institute, University of Minnesota
- Grigori Okoev
- Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota
- John Rogosheske
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Aleksandr Lazaryan
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Kristen Weiler
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Veronika Bachanova
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Brian C. Betts
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Bruce R. Blazar
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Claudio G. Brunstein
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Fiona He
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Shernan G. Holtan
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Murali Janakiram
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Radhika Gangaraju
- Department of Pediatrics, University of Alabama
- Joseph Maakaron
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Margaret L. MacMillan
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Armin Rashidi
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Erica D. Warlick
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Smita Bhatia
- Department of Pediatrics, University of Alabama
- Gregory Vercellotti
- Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota
- Daniel J. Weisdorf
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- Mukta Arora
- Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota
- DOI
- https://doi.org/10.1038/s41408-021-00488-2
- Journal volume & issue
-
Vol. 11,
no. 5
pp. 1 – 7
Abstract
Key points Patients with chronic GVHD after allogeneic hematopoietic cell transplantation are at high risk for thromboembolic events occurring years after diagnosis. More severe chronic GVHD, non-O donor-recipient ABO compared to O-O match and personal history of coronary artery disease are associated with higher risk of thromboembolic events.
