Installation of -SO2F groups onto primary amides

Jing Liu; Shi-Meng Wang; Njud S. Alharbi; Hua-Li Qin

doi:10.3762/bjoc.15.186

Beilstein Journal of Organic Chemistry (Aug 2019)

Installation of -SO2F groups onto primary amides

Jing Liu,
Shi-Meng Wang,
Njud S. Alharbi,
Hua-Li Qin

Affiliations

Jing Liu: State Key Laboratory of Silicate Materials for Architectures; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, China
Shi-Meng Wang: State Key Laboratory of Silicate Materials for Architectures; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, China
Njud S. Alharbi: Biotechnology Research group, Deportment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Hua-Li Qin: State Key Laboratory of Silicate Materials for Architectures; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, China

DOI: https://doi.org/10.3762/bjoc.15.186
Journal volume & issue: Vol. 15, no. 1
pp. 1907 – 1912

Abstract

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A protocol of SO2F2-mediated installation of sulfonyl fluoride onto primary amides has been developed providing a new portal to sulfur(VI) fluoride exchange (SuFEx) click chemistry. The generated molecules contain pharmaceutically important amide and -SO2F moieties for application in the discovery of new therapeutics.

Published in Beilstein Journal of Organic Chemistry

ISSN: 1860-5397 (Online)
Publisher: Beilstein-Institut
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.beilstein-journals.org/bjoc

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