Protein-targeted corona phase molecular recognition

Gili Bisker; Juyao Dong; Hoyoung D. Park; Nicole M. Iverson; Jiyoung Ahn; Justin T. Nelson; Markita P. Landry; Sebastian Kruss; Michael S. Strano

doi:10.1038/ncomms10241

Nature Communications (Jan 2016)

Protein-targeted corona phase molecular recognition

Gili Bisker,
Juyao Dong,
Hoyoung D. Park,
Nicole M. Iverson,
Jiyoung Ahn,
Justin T. Nelson,
Markita P. Landry,
Sebastian Kruss,
Michael S. Strano

Affiliations

Gili Bisker: Department of Chemical Engineering, Massachusetts Institute of Technology
Juyao Dong: Department of Chemical Engineering, Massachusetts Institute of Technology
Hoyoung D. Park: Department of Chemical Engineering, Massachusetts Institute of Technology
Nicole M. Iverson: Department of Biological Systems Engineering, University of Nebraska-Lincoln
Jiyoung Ahn: Department of Chemical Engineering, Massachusetts Institute of Technology
Justin T. Nelson: Department of Chemical Engineering, Massachusetts Institute of Technology
Markita P. Landry: Department of Chemical and Biomolecular Engineering, University of California Berkeley
Sebastian Kruss: Department of Chemistry, Institute for Physical Chemistry, Göttingen University
Michael S. Strano: Department of Chemical Engineering, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/ncomms10241
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Corona phase molecular recognition (CoPhMoRe) involves the deposition of a heteropolymer onto a nanoparticle surface, providing a recognition site for a given analyte. Here, the authors show that CoPhMoRe can be used to selectively detect proteins (fibrinogen) with high selectivity, including in a complex serum environment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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