Nature Communications (Apr 2019)
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
- Leanne K. Küpers,
- Claire Monnereau,
- Gemma C. Sharp,
- Paul Yousefi,
- Lucas A. Salas,
- Akram Ghantous,
- Christian M. Page,
- Sarah E. Reese,
- Allen J. Wilcox,
- Darina Czamara,
- Anne P. Starling,
- Alexei Novoloaca,
- Samantha Lent,
- Ritu Roy,
- Cathrine Hoyo,
- Carrie V. Breton,
- Catherine Allard,
- Allan C. Just,
- Kelly M. Bakulski,
- John W. Holloway,
- Todd M. Everson,
- Cheng-Jian Xu,
- Rae-Chi Huang,
- Diana A. van der Plaat,
- Matthias Wielscher,
- Simon Kebede Merid,
- Vilhelmina Ullemar,
- Faisal I. Rezwan,
- Jari Lahti,
- Jenny van Dongen,
- Sabine A. S. Langie,
- Tom G. Richardson,
- Maria C. Magnus,
- Ellen A. Nohr,
- Zongli Xu,
- Liesbeth Duijts,
- Shanshan Zhao,
- Weiming Zhang,
- Michelle Plusquin,
- Dawn L. DeMeo,
- Olivia Solomon,
- Joosje H. Heimovaara,
- Dereje D. Jima,
- Lu Gao,
- Mariona Bustamante,
- Patrice Perron,
- Robert O. Wright,
- Irva Hertz-Picciotto,
- Hongmei Zhang,
- Margaret R. Karagas,
- Ulrike Gehring,
- Carmen J. Marsit,
- Lawrence J. Beilin,
- Judith M. Vonk,
- Marjo-Riitta Jarvelin,
- Anna Bergström,
- Anne K. Örtqvist,
- Susan Ewart,
- Pia M. Villa,
- Sophie E. Moore,
- Gonneke Willemsen,
- Arnout R. L. Standaert,
- Siri E. Håberg,
- Thorkild I. A. Sørensen,
- Jack A. Taylor,
- Katri Räikkönen,
- Ivana V. Yang,
- Katerina Kechris,
- Tim S. Nawrot,
- Matt J. Silver,
- Yun Yun Gong,
- Lorenzo Richiardi,
- Manolis Kogevinas,
- Augusto A. Litonjua,
- Brenda Eskenazi,
- Karen Huen,
- Hamdi Mbarek,
- Rachel L. Maguire,
- Terence Dwyer,
- Martine Vrijheid,
- Luigi Bouchard,
- Andrea A. Baccarelli,
- Lisa A. Croen,
- Wilfried Karmaus,
- Denise Anderson,
- Maaike de Vries,
- Sylvain Sebert,
- Juha Kere,
- Robert Karlsson,
- Syed Hasan Arshad,
- Esa Hämäläinen,
- Michael N. Routledge,
- Dorret I. Boomsma,
- Andrew P. Feinberg,
- Craig J. Newschaffer,
- Eva Govarts,
- Matthieu Moisse,
- M. Daniele Fallin,
- Erik Melén,
- Andrew M. Prentice,
- Eero Kajantie,
- Catarina Almqvist,
- Emily Oken,
- Dana Dabelea,
- H. Marike Boezen,
- Phillip E. Melton,
- Rosalind J. Wright,
- Gerard H. Koppelman,
- Letizia Trevisi,
- Marie-France Hivert,
- Jordi Sunyer,
- Monica C. Munthe-Kaas,
- Susan K. Murphy,
- Eva Corpeleijn,
- Joseph Wiemels,
- Nina Holland,
- Zdenko Herceg,
- Elisabeth B. Binder,
- George Davey Smith,
- Vincent W. V. Jaddoe,
- Rolv T. Lie,
- Wenche Nystad,
- Stephanie J. London,
- Debbie A. Lawlor,
- Caroline L. Relton,
- Harold Snieder,
- Janine F. Felix
Affiliations
- Leanne K. Küpers
- MRC Integrative Epidemiology Unit, University of Bristol
- Claire Monnereau
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Gemma C. Sharp
- MRC Integrative Epidemiology Unit, University of Bristol
- Paul Yousefi
- MRC Integrative Epidemiology Unit, University of Bristol
- Lucas A. Salas
- Department of Epidemiology, Geisel School of Medicine at Dartmouth College
- Akram Ghantous
- Epigenetics Group, International Agency for Research on Cancer
- Christian M. Page
- Centre for Fertility and Health, Norwegian Institute of Public Health
- Sarah E. Reese
- Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park
- Allen J. Wilcox
- Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park
- Darina Czamara
- Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry
- Anne P. Starling
- Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus
- Alexei Novoloaca
- Epigenetics Group, International Agency for Research on Cancer
- Samantha Lent
- Department of Biostatistics, Boston University School of Public Health
- Ritu Roy
- HDF Comprehensive Cancer Center, University of California
- Cathrine Hoyo
- Department of Biological Sciences, North Carolina State University
- Carrie V. Breton
- Department of Preventive Medicine, University of Southern California
- Catherine Allard
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
- Allan C. Just
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
- Kelly M. Bakulski
- Department of Epidemiology, School of Public Health, University of Michigan
- John W. Holloway
- Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton
- Todd M. Everson
- Department of Environmental Health, Rollins School of Public Health at Emory University
- Cheng-Jian Xu
- University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children’s Hospital, Groningen Research Institute for Asthma and COPD
- Rae-Chi Huang
- Telethon Kids Institute, University of Western Australia
- Diana A. van der Plaat
- University of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC)
- Matthias Wielscher
- Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London
- Simon Kebede Merid
- Institute of Environmental Medicine, Karolinska Institutet
- Vilhelmina Ullemar
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Faisal I. Rezwan
- Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital
- Jari Lahti
- Helsinki Collegium for Advanced Studies, University of Helsinki
- Jenny van Dongen
- Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam
- Sabine A. S. Langie
- VITO - Health
- Tom G. Richardson
- MRC Integrative Epidemiology Unit, University of Bristol
- Maria C. Magnus
- MRC Integrative Epidemiology Unit, University of Bristol
- Ellen A. Nohr
- Research Unit for Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark
- Zongli Xu
- Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam
- Liesbeth Duijts
- Division of Human Nutrition and Health, Wageningen University
- Shanshan Zhao
- Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park
- Weiming Zhang
- Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus
- Michelle Plusquin
- Centre for Environmental Sciences, Hasselt University
- Dawn L. DeMeo
- Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Olivia Solomon
- School of Oral and Dental Sciences, University of Bristol
- Joosje H. Heimovaara
- University of Groningen, University Medical Center Groningen, Department of Epidemiology
- Dereje D. Jima
- Center for Human Health and the Environment, North Carolina State University
- Lu Gao
- Department of Preventive Medicine, University of Southern California
- Mariona Bustamante
- ISGlobal, Bacelona Institute for Global Health
- Patrice Perron
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
- Robert O. Wright
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
- Irva Hertz-Picciotto
- Department of Public Health Sciences, School of Medicine, University of California Davis MIND Institute
- Hongmei Zhang
- Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis
- Margaret R. Karagas
- Department of Epidemiology, Geisel School of Medicine at Dartmouth College
- Ulrike Gehring
- Institute for Risk Assessment Sciences, Utrecht University
- Carmen J. Marsit
- Department of Environmental Health, Rollins School of Public Health at Emory University
- Lawrence J. Beilin
- Medical School, University of Western Australia
- Judith M. Vonk
- University of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC)
- Marjo-Riitta Jarvelin
- Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London
- Anna Bergström
- Institute of Environmental Medicine, Karolinska Institutet
- Anne K. Örtqvist
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Susan Ewart
- College of Veterinary Medicine, Michigan State University
- Pia M. Villa
- Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital
- Sophie E. Moore
- Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Gonneke Willemsen
- Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam
- Arnout R. L. Standaert
- VITO - Health
- Siri E. Håberg
- Centre for Fertility and Health, Norwegian Institute of Public Health
- Thorkild I. A. Sørensen
- MRC Integrative Epidemiology Unit, University of Bristol
- Jack A. Taylor
- Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park
- Katri Räikkönen
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki
- Ivana V. Yang
- Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus
- Katerina Kechris
- Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center Rotterdam
- Tim S. Nawrot
- Centre for Environmental Sciences, Hasselt University
- Matt J. Silver
- Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Yun Yun Gong
- School of Food Sciences and Nutrition, University of Leeds
- Lorenzo Richiardi
- Department of Medical Sciences, University of Turin
- Manolis Kogevinas
- ISGlobal, Bacelona Institute for Global Health
- Augusto A. Litonjua
- Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Brenda Eskenazi
- Children’s Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California
- Karen Huen
- Children’s Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California
- Hamdi Mbarek
- Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam
- Rachel L. Maguire
- Department of Biological Sciences, North Carolina State University
- Terence Dwyer
- The George Institute for Global Health, Nuffield Department of Women’s & Reproductive Health, University of Oxford
- Martine Vrijheid
- ISGlobal, Bacelona Institute for Global Health
- Luigi Bouchard
- Department of Biochemistry, Université de Sherbrooke
- Andrea A. Baccarelli
- Laboratory of Precision Environmental Biosciences, Columbia University Mailman School of Public Health
- Lisa A. Croen
- Division of Research, Kaiser Permanente Northern California
- Wilfried Karmaus
- Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis
- Denise Anderson
- Telethon Kids Institute, University of Western Australia
- Maaike de Vries
- University of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC)
- Sylvain Sebert
- Center for Life Course Health Research, Faculty of Medicine, University of Oulu
- Juha Kere
- Folkhälsan Institute of Genetics, Helsinki, and Research Programs Unit, Molecular Neurology, University of Helsinki
- Robert Karlsson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Syed Hasan Arshad
- Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton
- Esa Hämäläinen
- HUSLAB and the Department of Clinical Chemistry, University of Helsinki
- Michael N. Routledge
- LICAMM, School of Medicine, Univeristy of Leeds
- Dorret I. Boomsma
- Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam
- Andrew P. Feinberg
- Center for Epigenetics, Johns Hopkins University School of Medicine
- Craig J. Newschaffer
- AJ Drexel Autism Institute, Drexel University
- Eva Govarts
- VITO - Health
- Matthieu Moisse
- KU Leuven – University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND)
- M. Daniele Fallin
- Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University
- Erik Melén
- Institute of Environmental Medicine, Karolinska Institutet
- Andrew M. Prentice
- Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Eero Kajantie
- National Institute for Health and Welfare, Helsinki and Oulu
- Catarina Almqvist
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Emily Oken
- Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute
- Dana Dabelea
- Department of Epidemiology, Colorado School of Public Health, and Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Anschutz Medical Campus
- H. Marike Boezen
- University of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC)
- Phillip E. Melton
- Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, University of Western Australia
- Rosalind J. Wright
- Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai
- Gerard H. Koppelman
- University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children’s Hospital, Groningen Research Institute for Asthma and COPD
- Letizia Trevisi
- Department of Global Health and Social Medicine, Harvard Medical School
- Marie-France Hivert
- Department of Medicine, Universite de Sherbrooke
- Jordi Sunyer
- ISGlobal, Bacelona Institute for Global Health
- Monica C. Munthe-Kaas
- Norwegian Institute of Public Health
- Susan K. Murphy
- Department of Obstetrics and Gynecology, Duke University Medical Center
- Eva Corpeleijn
- University of Groningen, University Medical Center Groningen, Department of Epidemiology
- Joseph Wiemels
- Department of Epidemiology and Biostatistics, University of California
- Nina Holland
- Children’s Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California
- Zdenko Herceg
- Epigenetics Group, International Agency for Research on Cancer
- Elisabeth B. Binder
- Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry
- George Davey Smith
- MRC Integrative Epidemiology Unit, University of Bristol
- Vincent W. V. Jaddoe
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Rolv T. Lie
- Centre for Fertility and Health, Norwegian Institute of Public Health
- Wenche Nystad
- Department for Non-Communicable Diseases, Norwegian Institute for Public Health
- Stephanie J. London
- Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park
- Debbie A. Lawlor
- MRC Integrative Epidemiology Unit, University of Bristol
- Caroline L. Relton
- MRC Integrative Epidemiology Unit, University of Bristol
- Harold Snieder
- University of Groningen, University Medical Center Groningen, Department of Epidemiology
- Janine F. Felix
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- DOI
- https://doi.org/10.1038/s41467-019-09671-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Birthweight has been found to associate with later-life health outcomes. Here the authors perform a meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, identifying differentially methylated CpGs in neonatal blood that associate with birthweight.
