Autosomal dominant non-epidermolytic palmoplantar hyperkeratosis in a Nigerian girl

Abstract

Palmoplantar keratoderma (PPK) is a hereditary cutaneous disorder characterized by a marked hyperkeratosis of the palms and soles. A variant that was inherited in an autosomal dominant form was highlighted in a 20-month-old girl-child. The proband was brought to the Paediatric Outpatient Department by her mother because of an unusual but a familiar thickening of the palms and soles, having married to the proband’s father who is having a similarly thickened palms and soles. The disorder was noticed in the proband, two weeks after birth, initially with reddening of the palms and soles, followed by blistering and eventual thickening of the palms and soles, occurring over one-and-half months. There were no associated systemic symptoms and the hair, the teeth and nails were not affected. PPK, although a common cutaneous disorder, has been reported sparingly in Nigeria. The index case was diagnosed histologically to be the nonepidermolytic type and a high dose of vitamin A and salycylic acid ointment were administered with a little improvement in the keratoses.

Keywords

• autosomal dominant
• palmoplantar hyperkeratosis
• girlchild
• ichthyosis
• nigeria