Communications Biology (Feb 2023)

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening

  • Marie Miglianico,
  • Judith M. Bolscher,
  • Martijn W. Vos,
  • Karin J. M. Koolen,
  • Marloes de Bruijni,
  • Deeya S. Rajagopal,
  • Emily Chen,
  • Michael Kiczun,
  • David Gray,
  • Brice Campo,
  • Robert W. Sauerwein,
  • Koen J. Dechering

DOI
https://doi.org/10.1038/s42003-023-04599-3
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 10

Abstract

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A high-throughput screening pipeline tests the feasibility of targeting the sporozoite stage of P. falciparum through chemical interventions and identifies gramicidin as a potential sporontocidal agent.