Polymorphism of Pro12Ala and C1431T PPARγin the pathogenesis of Graves' orbitopathy

Abstract

AIM: to examine the association of polymorphisms Pro12Ala and C1431T PPARγwith the development of thyroid eye disease (TEO). Materials and methods. A total of 88 people: 52 patients with TEO, 36 – healthy individuals. Identified polymorphisms Pro12Ala and C1431T PPARγby PCR. Results. In more common TEO homozygous genotypes Pro/Pro and Ala/Ala (χ 2 = 6,035, p = 0.049) and allele Ala (χ 2 = 15,062, p 0,001) polymorphism Pro12Ala; geno types C/C and T/T (χ 2 = 28,34, p 0,001), the allele C (χ 2 = 15,06, p 0,001) polymorphism C1431T PPARγ, than in the control. The relative risk of TEO in the Ala/Ala genotype of 1.73 (95% CI, 1.45–2.08), with C/T genotype of 0.61 (95% CI, 0.39–0.96). The odds ratio for C/T genotype in patients with TEO 0.33 (95% CI, 0.13–0.82).

Keywords

• pparg
• pro12ala
• c1431t
• thyroid eye disease
• endocrine ophthalmopathy
• graves’ ophthalmopathy
• pparg
• pro12ala
• c1431t