Frontiers in Aging Neuroscience (Jun 2021)
Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers
- Jorge Piano Simoes,
- Elza Daoud,
- Maryam Shabbir,
- Sana Amanat,
- Kelly Assouly,
- Kelly Assouly,
- Kelly Assouly,
- Roshni Biswas,
- Roshni Biswas,
- Chiara Casolani,
- Chiara Casolani,
- Chiara Casolani,
- Albi Dode,
- Falco Enzler,
- Laure Jacquemin,
- Laure Jacquemin,
- Mie Joergensen,
- Mie Joergensen,
- Tori Kok,
- Nuwan Liyanage,
- Nuwan Liyanage,
- Matheus Lourenco,
- Matheus Lourenco,
- Punitkumar Makani,
- Punitkumar Makani,
- Muntazir Mehdi,
- Anissa L. Ramadhani,
- Anissa L. Ramadhani,
- Constanze Riha,
- Jose Lopez Santacruz,
- Jose Lopez Santacruz,
- Axel Schiller,
- Stefan Schoisswohl,
- Natalia Trpchevska,
- Eleni Genitsaridi,
- Eleni Genitsaridi
Affiliations
- Jorge Piano Simoes
- Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
- Elza Daoud
- Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
- Maryam Shabbir
- Hearing Sciences, Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom
- Sana Amanat
- Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO - Centre for Genomics and Oncological Research Pfizer/University of Granada/Junta de Andalucía, PTS, Granada, Spain
- Kelly Assouly
- Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, Netherlands
- Kelly Assouly
- Department of Clinical and Experimental Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, Netherlands
- Kelly Assouly
- Cochlear Technology Centre, Mechelen, Belgium
- Roshni Biswas
- Hearing Sciences, Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom
- Roshni Biswas
- Laboratory of Lifestyle Epidemiology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
- Chiara Casolani
- Hearing Systems, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
- Chiara Casolani
- 0Oticon A/S, Smoerum, Denmark
- Chiara Casolani
- 1Interacoustics Research Unit, Lyngby, Denmark
- Albi Dode
- 2Institute of Databases and Information Systems, Ulm University, Ulm, Germany
- Falco Enzler
- Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
- Laure Jacquemin
- 3Department of Otorhinolaryngology Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium
- Laure Jacquemin
- 4Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium
- Mie Joergensen
- Hearing Systems, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
- Mie Joergensen
- 5WS Audiology, Lynge, Denmark
- Tori Kok
- 6Ear Institute, University College London, London, United Kingdom
- Nuwan Liyanage
- 7University of Zurich, Zurich, Switzerland
- Nuwan Liyanage
- 8Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland
- Matheus Lourenco
- 9Experimental Health Psychology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands
- Matheus Lourenco
- 0Health Psychology Research Group, Faculty of Psychology and Educational Sciences, University of Leuven, Leuven, Belgium
- Punitkumar Makani
- 1Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
- Punitkumar Makani
- 2Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, Groningen, Netherlands
- Muntazir Mehdi
- 3Institute of Distributed Systems, Ulm University, Ulm, Germany
- Anissa L. Ramadhani
- 4Radiological Sciences, Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom
- Anissa L. Ramadhani
- 5Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom
- Constanze Riha
- 6Chair of Neuropsychology, Department of Psychology, University of Zurich, Zurich, Switzerland
- Jose Lopez Santacruz
- 1Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
- Jose Lopez Santacruz
- 2Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, Groningen, Netherlands
- Axel Schiller
- Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
- Stefan Schoisswohl
- Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
- Natalia Trpchevska
- 7Department of Physiology and Pharmacology, Experimental Audiology Laboratory, Karolinska Institutet, Stockholm, Sweden
- Eleni Genitsaridi
- Hearing Sciences, Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom
- Eleni Genitsaridi
- 8Nottingham Biomedical Research Centre, National Institute for Health Research, Nottingham, United Kingdom
- DOI
- https://doi.org/10.3389/fnagi.2021.647285
- Journal volume & issue
-
Vol. 13
Abstract
Tinnitus can be a burdensome condition on both individual and societal levels. Many aspects of this condition remain elusive, including its underlying mechanisms, ultimately hindering the development of a cure. Interdisciplinary approaches are required to overcome long-established research challenges. This review summarizes current knowledge in various tinnitus-relevant research fields including tinnitus generating mechanisms, heterogeneity, epidemiology, assessment, and treatment development, in an effort to highlight the main challenges and provide suggestions for future research to overcome them. Four common themes across different areas were identified as future research direction: (1) Further establishment of multicenter and multidisciplinary collaborations; (2) Systematic reviews and syntheses of existing knowledge; (3) Standardization of research methods including tinnitus assessment, data acquisition, and data analysis protocols; (4) The design of studies with large sample sizes and the creation of large tinnitus-specific databases that would allow in-depth exploration of tinnitus heterogeneity.
Keywords
