Dynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury

Abstract

Aim. To investigate the relationship between nitric oxide gasotransmitter and acid, alkaline ribonucleases enzymes in patients with severe traumatic brain injury and to determine the dynamics of peculiarities in case of their changes during the course of treatment. Material and Methods. The study investigated diagnostic data and treatment outcomes of 72 patients with severe traumatic brain injury aged 18-76 years (mean age 42.26±15.02 years), grouped into four groups by the Glasgow Outcome Scale: "Death", "Significant disability ","Moderate disability ", "Recovery". Results and Discussion. A significant growth of nitric oxide indicatorwas observed in patients with adverse effects (subsequently died or remained disabled) and it decreased over time to treat patient groups with relatively favorable treatment outcomes (moderate disability and recovery). The diagnostic markers of further adverse effects on life at the start of treatment (first day) include the level of urinary nitric oxide below 1.1 µmol/l and the level of RNase less than 25 IU/ml respectively. The direct correlation relationship between the value of nitric oxide level and RNase level on the 1st, 3rd, 7th and 9th (p<0.05) days of treatment has been proved. Conclusions. The results of the study would be important for the prompt assessment of the patient's condition and decision making regarding the treatment methods, minimizing the effect of the injury and predicting probable consequences of traumatic brain injury.

Keywords

• traumatic brain injury, nitric oxide, ribonuclease, death, treatment consequences