Current Oncology (Mar 2024)

Ductal Adenocarcinoma of the Prostate with Novel Genetic Alterations Characterized by Next-Generation Sequencing

  • Alexandra Zara Rozalen,
  • Jose Manuel Martin,
  • Rithika Rajendran,
  • Maneesh Jain,
  • Victor E. Nava

DOI
https://doi.org/10.3390/curroncol31030118
Journal volume & issue
Vol. 31, no. 3
pp. 1556 – 1561

Abstract

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Ductal adenocarcinoma of the prostate (DAP) is an uncommon variant of prostate cancer associated with aggressive disease and poor outcome. It presents most frequently as a mixed tumor combined with acinar adenocarcinoma. Although the histopathological features of DAP are well known, its genomic characteristics are still evolving, prompting the suggestion that all DAP would benefit from molecular analysis with the purpose of improving tumor recognition, genetic classification, and, ultimately, personalized therapy. Herein, we report a case of DAP with novel genetic alterations (BCOR P1153S, ERG M219I, KDR A750E, POLE S1896P, and RAD21 T461del).

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