Chemopreventionof long-term oncological consequences on the model of radiation carcinogenesis in female rats

Abstract

A comparative study of the anticarcinogenic activity of synthetic polyamine inhibitor α-difluoromethylornithine (DFMO) and three plant drugs on the model of radiation carcinogenesis was carried out in 615 female Wistar rats subjected to total body γ-irradiation at a dose of 4 Gy. After the irradiation the rats were given for 16 months with drinking water DFMO at a concentration of 2 g/l, tincture from biomass of tissue culture of ginseng root (bioginseng) at a concentration of 20 ml/l, tincture of Siberian ginseng root, or tincture of maral root rhizome at a concentration of 10 ml/l each. The incidence and multiplicity of malignant and benign tumors of the mammary gland, endocrine and reproductive organs, and other localizations were assessed. Bioginseng had the strongest anticarcinogenic activity. In comparison with the irradiated control bioginseng significantly decreased the overall incidence and multiplicity of tumors by 35 % and 58 %, correspondingly, and also significantly decreased ones of malignant tumors by 60 % and 65 %, correspondingly. Anticarcinogenic efficiency of DFMO was weaker compared with bioginseng and Siberian ginseng had the most weak anticarcinogenic activity. Maral root did not influence significantly on the radiation carcinogenesis. The drugs of ginseng are the most promising for chemoprevention of late oncologic consequences of radiation expo

Keywords

• радиационный канцерогенез
• крысы самки
• α-дифторметилорнитин
• биоженьшень
• элеутерококк
• левзея